MAVS; VISA Antibody 5 Publications

Rabbit Polyclonal| Catalog number: 14341-1-AP

Featured Product KD/KO validated

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Con: 29 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
HEK-293 cells, HeLa cells, human heart tissue, Jurkat cells

Positive IP detected in:
HEK-293 cells

Positive IHC detected in:
human skin tissue

Positive IF detected in:
Hela cells

Recommended dilution:
WB : 1:1000-1:4000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:100-1:500
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
mitochondrial antiviral signaling protein

Calculated molecular weight:
57 kDa

Observed molecular weight:
70-75 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
MAVS

Synonyms
CARDIF, DKFZp547C224, DKFZp666M015, FLJ27482, FLJ35386, FLJ38051, FLJ41962, IPS 1, IPS1, KIAA1271, MAVS, VISA
Background

Mitochondrial antiviral-signaling protein (MAVS) is also known as virus-induced-signaling adapter (VISA) or interferon beta promoter stimulator protein 1 (IPS-1), it is widely involved and required for innate immune defense against viruses. MAVS, present in T cells, monocytes, epithelial cells and hepatocytes, contains CARD and transmembrane domains which are essential for antiviral functions. MAVS is able to interact with various cellular proteins including DDX58/RIG-I, IFIH1/MDA5, TRAF2, TRAF6, TMEM173/MITA, IFIT3 and etc. It can undergoe phosphorylation on multiple sites and ubiquitination, which may together cause the molecular weight migrate to about 70 kDa despite the predicated 57 kDa.


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