CD146/MCAM Antibody 4 Publications

Rabbit Polyclonal| Catalog number: 17564-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 60 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
HepG2 cells, A375 cells

Positive IP detected in:
HeLa cells, HepG2 cells

Positive IHC detected in:
human spleen tissue, human kidney tissue, human heart tissue, human brain tissue, human placenta tissue, human ovary tumor tissue, human testis tissue, human lung tissue

Positive IF detected in:
HeLa cells

Positive FC detected in:
HUVEC cells

Recommended dilution:
WB : 1:1000-1:4000
IP : 0.5-4.0 ug for IP and 1:500-1:3000 for WB
IHC : 1:20-1:200
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
melanoma cell adhesion molecule

Calculated molecular weight:
646aa,72 kDa

Observed molecular weight:
113-120 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
MCAM

Synonyms
CD146, MCAM, MUC18
Background

CD146, also known as melanoma cell adhesion molecule (MCAM) or MUC18, originally identified as a biomarker of melanoma progression, is a transmembrane glycoprotein belonging to the immunoglobulin (Ig) superfamily (PMID: 8378324). Structurally, it consists of five Ig domains, a transmembrane domain, and a cytoplasmic region. In normal adult tissue, CD146 is primarily expressed by vascular endothelium and smooth muscle. CD146 is a key cell adhesion protein in vascular endothelial cell activity and angiogenesis, and has been used as marker of circulating endothelium cells (CECs) (PMID: 19356677).


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