Back

MMP7 Antibody 20 Publications

Rabbit Polyclonal| Catalog number: 10374-2-AP

Featured Product KD/KO validated

  • Print page
  • Download PDF

-_-

Freight/Packing

Con: 55 μg/150 μl

Choose size:

Please visit your regions distributor:

Request quote for
bulk/custom formulations

Special offer: Add control/tag antibody for $99
Load more
Tested Applications
Applications:
ELISA, IHC, WB
Application not tested? Please see our Guarantee


Images See all

10374-2-AP;NIH/3T3 cells

NIH/3T3 cells were subjected to SDS PAGE followed by western blot with 10374-2-AP(MMP7 antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours

10374-2-AP;human pancreas cancer tissue

Immunohistochemical of paraffin-embedded human pancreas cancer using 10374-2-AP(MMP7 antibody) at dilution of 1:100 (under 10x lens)

Species specificity:
human, mouse
Positive WB detected in:
NIH/3T3 cells, COLO 320 cells, human placenta tissue, mouse lung tissue
Positive IHC detected in:
human pancreas cancer tissue, human pancreas cancer tissue, human stomach tissue
Recommended dilution:
WB : 1:500-1:1000
IHC : 1:50-1:200

Product Information

Source:
Rabbit
Purification method:
Antigen affinity purification
Isotype:
IgG
Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information

Immunogen:
MMP7 fusion protein ag0550
Full name:
matrix metallopeptidase 7 (matrilysin, uterine)
Calculated molecular weight:
29 kDa
Observed molecular weight:
28-30 kDa
GenBank accession number:
BC003635
Gene ID (NCBI):
4316
Gene symbol
MMP7
Synonyms
Matrilysin, Matrin, Matrix metalloproteinase 7, MMP 7, MMP7, MPSL1, PUMP 1, Pump 1 protease, PUMP1, Uterine metalloproteinase
Background

Matrix metalloproteinase-7 (MMP-7)/ matrilysin is a member of the MMP family, but is structurally different from the other MMPs by virtue of the absence of a conserved COOH-terminal protein domain. MMPs are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and cancer metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP-7 degrades proteoglycans, fibronectin, elastin and casein, and is involved in wound healing, tumor progression, pulmonary fibrosis, and development of choroidal neovascularization in age-related macular degeneration. The expression of MMP-7 is increased in most tumors. The gene encoding MMP-7 is part of a cluster of MMP genes which localize to chromosome 11q22.3.


Back
to top