MOG Polyclonal antibody

MOG Polyclonal Antibody for WB, IHC, ELISA

Host / Isotype

Rabbit / IgG


human, mouse, rat





Cat no : 12690-1-AP


MOG, MOGIG 2, myelin oligodendrocyte glycoprotein

Tested Applications

Positive WB detected inmouse brain tissue, rat brain tissue
Positive IHC detected inmouse brain tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Recommended dilution

Western Blot (WB)WB : 1:500-1:3000
Immunohistochemistry (IHC)IHC : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

12690-1-AP targets MOG in WB, IF, IHC, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Cited Reactivityhuman, mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen MOG fusion protein Ag3273
Full Name myelin oligodendrocyte glycoprotein
Calculated Molecular Weight 295 aa, 34 kDa
Observed Molecular Weight 25-28 kDa
GenBank Accession NumberBC035938
Gene Symbol MOG
Gene ID (NCBI) 4340
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

Myelin/oligodendrocyte glycoprotein (MOG), a 23~28 kDa glycoprotein, a myelin antigen at the outer surface of the central nervous system (CNS) myelin sheath, which may trigger T-cell as well as B-cell responses. It therefore constitutes a pivotal target for autoimmune responses, which result in inflammation and also demyelination in the CNS. Its presence on the outer- most lamellae of mature CNS myelin and its late appearance during myelinogenesis suggest that it contributes to myelin maturation or maintenance. 10 isoforms of MOG produced by alternative splicing have been described, and heterodimers may be formed between the different isoforms. Defects in MOG are the cause of narcolepsy type 7 (NRCLP7), a neurological disabling sleep disorder characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, cataplexy, hypnagogic hallucinations, and sleep paralysis. Role of MOG in the pathogenesis of multiple sclerosis (MS) has been reported but remains to be clarified.


Product Specific Protocols
WB protocol for MOG antibody 12690-1-APDownload protocol
IHC protocol for MOG antibody 12690-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols




Activity-dependent modulation of synapse-regulating genes in astrocytes.

Authors - Isabella Farhy-Tselnicker

Int J Mol Sci

The Distribution of GPR17-Expressing Cells Correlates with White Matter Inflammation Status in Brain Tissues of Multiple Sclerosis Patients.

Authors - Jacopo Angelini


ST8SIA2 promotes oligodendrocyte differentiation and the integrity of myelin and axons.

Authors - Lukasz Mateusz Szewczyk

J Neuroinflammation

Interleukin-9 regulates macrophage activation in the progressive multiple sclerosis brain.

Authors - Gloria Donninelli

Brain Pathol

Overexpression of the ubiquitin-editing enzyme A20 in the brain lesions of Multiple Sclerosis patients: moving from systemic to central nervous system inflammation.

Authors - Simona Perga

J Virol

Identification of the myelin oligodendrocyte glycoprotein as a cellular receptor for rubella virus.

Authors - Cong Haolong H


The reviews below have been submitted by verified Proteintech customers who received an incentive forproviding their feedback.


Reyes (Verified Customer) (03-01-2024)

MOG (in red) worked nicely showing the mielinated axons in my paraffin human brain cortex sections in IF

  • Applications: Immunofluorescence
  • Primary Antibody Dilution: 1:100
  • Cell Tissue Type: Human Brain Cortex
MOG Antibody Immunofluorescence validation (1:100 dilution) in Human Brain Cortex (Cat no:12690-1-AP)