|Positive WB detected in
|HL-60 cells, Jurkat cells, MOLT-4 cells
|Positive IP detected in
|Western Blot (WB)
|WB : 1:1000-1:8000
|IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate
|It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
|Sample-dependent, check data in validation data gallery
17800-1-AP targets MYB/c-Myb in WB, IP, IF, CoIP, ELISA applications and shows reactivity with human samples.
|Host / Isotype
|Rabbit / IgG
|MYB/c-Myb fusion protein Ag12021
|v-myb myeloblastosis viral oncogene homolog (avian)
|Calculated molecular weight
|640 aa, 72 kDa
|Observed molecular weight
|40-50 kDa, 72-80 kDa
|GenBank accession number
|Gene ID (NCBI)
|Antigen affinity purification
|PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
|Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.
The MYB protein is a transcription factor that plays a key role in regulating the proliferation/differentiation of progenitor cells in bone marrow, colonic crypts, and neurogenic niches [PMID:18574464]. It is involved in the regulation of epithelial-to-mesenchymal transition (EMT) and invasion in neuroblastoma, colon carcinoma, and embryonic kidney cells through the upregulation of the transcription repressor Slug [PMID:20622260]. It also a DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3', and plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells. MYB exists some isoforms with MV 85, 75, 72, 68, 63 and 40 kDa.
NLRP3 phosphorylation in its LRR domain critically regulates inflammasome assembly.
Tcf1 and Lef1 provide constant supervision to mature CD8+ T cell identity and function by organizing genomic architecture.
SND1 acts as an anti-apoptotic factor via regulating the expression of lncRNA UCA1 in hepatocellular carcinoma.
Front Endocrinol (Lausanne)
KRT17 from skin cells with high glucose stimulation promotes keratinocytes proliferation and migration
Front Med (Lausanne)
Lidocaine and Bupivacaine Downregulate MYB and DANCR lncRNA by Upregulating miR-187-5p in MCF-7 Cells.
Cancer Genomics Proteomics
Myb Repression Mediates Stat5b-knockdown-induced Apoptosis and Inhibits Proliferation of Glioblastoma Stem Cells