Validation Data Gallery
|Positive WB detected in||Jurkat cells, HeLa cells, K-562 cells, Neuro-2a cells, NIH/3T3 cells|
|Positive IP detected in||HeLa cells|
|Western Blot (WB)||WB : 1:1000-1:6000|
|Immunoprecipitation (IP)||IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB|
|Sample-dependent, check data in validation data gallery|
14611-1-AP targets MYO18A in WB, IP, IHC, IF, FC applications and shows reactivity with human, mouse, rat samples.
|Tested Reactivity||human, mouse, rat|
|Cited Reactivity||human, mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||MYO18A fusion protein Ag6185|
|Full Name||myosin XVIIIA|
|Calculated molecular weight||233 kDa|
|Observed molecular weight||230 kDa, 190 kDa|
|GenBank accession number||BC039612|
|Gene ID (NCBI)||399687|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
MYO18A is an unconventional myosin that may play a role in the stabilization and organization of the actin cytoskeleton. Recently MYO18A has been identified as the receptor of SP and is responsible for clearance of SP-A-opsonized bacteria in in vivo infection. Two different isoforms of mouse Myo18A have been identified: Myo18A-alpha and Myo18A-beta as 230- and 190-kDa proteins, respectively. Myo18a-alpha colocalizes with the ER-Golgi complex and with membrane ruffles and filopodia, while Myo18a-beta localizes diffusely to the cytoplasm.
APOL1 C-Terminal Variants May Trigger Kidney Disease through Interference with APOL3 Control of Actomyosin.
GM-CSF modulates pulmonary resistance to influenza A infection.
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A novel isoform of myosin 18A (Myo18Aγ) is an essential sarcomeric protein in mouse heart.
J Cell Sci
Pushing myelination: developmental regulation of myosin expression drives oligodendrocyte morphological differentiation.
J Biol Chem
Surfactant protein A (SP-A)-mediated clearance of Staphylococcus aureus involves binding of SP-A to the staphylococcal adhesin eap and the macrophage receptors SP-A receptor 210 and scavenger receptor class A.
Unbiased Profiling of the Human Proinsulin Biosynthetic Interaction Network Reveals a Role For Peroxiredoxin 4 in Proinsulin Folding.