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Recombinant Mouse ACE2 protein (rFc Tag)

Species

Mouse

Purity

>90 %, SDS-PAGE

Tag

rFc Tag

Activity

not tested

Cat no : Eg2834

Validation Data Gallery

  • Purity of Recombinant Mouse ACE2 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Mouse ACE2 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

Product Information

Purity >90 %, SDS-PAGE
Endotoxin <0.1 EU/μg protein, LAL method
Activity 
Not tested
Expression HEK293-derived Mouse ACE2 protein Gln18-Thr740 (Accession# Q8R0I0-1) with a rabbit IgG Fc tag at the C-terminus.
GeneID 70008
Accession Q8R0I0-1
PredictedSize 109.5 kDa
SDS-PAGE 110-130 kDa, reducing (R) conditions
Formulation Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
Reconstitution Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
Storage Conditions
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

ACE2 (Angiotensin-converting enzyme 2), also named as ACEH, is a zinc metalloprotease of the ACE family and a critical regulator of the reninangiotensin system. ACE2 has a more restricted tissue distribution than ACE, being found predominantly in the heart, kidneys, and testes although low levels have been detected in a variety of tissues. ACE2 has been shown to be a functional receptor of the human coronaviruses SARS-CoV and SARS-CoV-2. The expression level and expression pattern of human ACE2 in different tissues might be critical for the susceptibility, symptoms, and outcome of 2019-nCoV/SARS-CoV-2 infection. It can be used as a potential therapeutic target of SARS-CoV-2.

References:

1. Lambert DW, et al. (2005) J Biol Chem. 280(34):30113-9. 
2. Hoffmann M, et al. (2020) Cell. 181(2):271-280.e8. 
3. Cao Y, et al. (2020) Cell Discov. 6:11. 
4. Zhang H, et al. (2020) Intensive Care Med. 46(4):586-590. 
5. Warner FJ, et al. (2005) J Biol Chem. 280(47):39353-62.