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Recombinant Mouse IL-13RA2 protein (rFc Tag) (HPLC verified)

Species

Mouse

Purity

>90 %, SDS-PAGE
>90 %, SEC-HPLC

Tag

rFc Tag

Activity

not tested

Cat no : Eg3118

Validation Data Gallery

  • Purity of Recombinant Mouse IL-13RA2 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Mouse IL-13RA2 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

  • The purity of Mouse IL-13RA2 was greater than 90% as determined by SEC-HPLC.

    The purity of Mouse IL-13RA2 was greater than 90% as determined by SEC-HPLC.

Product Information

Purity >90 %, SDS-PAGE
>90 %, SEC-HPLC
Endotoxin <0.1 EU/μg protein, LAL method
Activity 
Not tested
Expression HEK293-derived Mouse IL-13RA2 protein Leu22-Lys334 (Accession# O88786-1) with a rabbit IgG Fc tag at the C-terminus.
GeneID 16165
Accession O88786-1
PredictedSize 62.5 kDa
SDS-PAGE 68-80 kDa, reducing (R) conditions
Formulation Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
Reconstitution Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
Storage Conditions
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

The protein encoded by the Il13ra2 gene is closely related to Il13ra1, a subunit of the interleukin 13 receptor complex. This protein binds IL13 with high affinity but lacks a cytoplasmic domain and does not function as a signal mediator. It is reported to play a role in the internalization of IL13. It acts as a decoy receptor for IL-13, diminishing its STAT6-mediated effector functions. It has been implicated in the pathogenesis of inflammatory bowel disease (IBD). Mouse models have been used to study the function of Il13ra2 in IBD, and its human ortholog IL13RA2 is a promising candidate for the development of therapeutic strategies for IBD.

References:

1. Seblani M, Zannikou M, et al. (2024) Res Sq. rs.3.rs-5398280. 
2. Zhang T, Zhu M, et al. (2024) J Adv Res. S2090-1232(24)00082-1. 
3. Marquardt RM, Lee K, et al. (2020) Biol Reprod. 103(4):760-768. 
4. Saka M, Amano T, et al. (2010) J Neurosurg. 113(2):270-9.