Recombinant Mouse Mbl2 protein (rFc Tag)

Species

Mouse

Purity

>90 %, SDS-PAGE

Tag

rFc Tag

Activity

not tested

Cat no : Eg3157

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Validation Data Gallery

• 

  Purity of Recombinant Mouse Mbl2 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

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Product Information

• Purity: >90 %, SDS-PAGE
• Endotoxin: <0.1 EU/μg protein, LAL method
• Activity:

  Not tested

• Expression: HEK293-derived Mouse Mbl2 protein Glu19-Asp244 (Accession# P41317) with a rabbit IgG Fc tag at the C-terminus.
• GeneID: 17195
• Accession: P41317
• PredictedSize: 50.0 kDa
• SDS-PAGE: 48-60 kDa, reducing (R) conditions
• Formulation: Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
• Reconstitution: Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
• Storage Conditions:
  It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
• Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

Mbl2 (mannose-binding lectin 2), a member of the multimeric lectin family, is crucial in immune regulation and tumor development. Mbl2 serves as a crucial regulator of the innate immune response and represents a prime candidate for genetic association studies in cancer due to its genomic heterogeneity. Mbl2 activates a complement through the lectin pathway, recognizing and removing pathogens, such as microorganisms and viruses, apoptotic cells, and necrotic cells.

References:

1. Maury C. P., et al. (2007). J Intern Med. Oct;262(4):466-9. 
2. Baccarelli A, et al. (2006). Int J Cancer. Oct 15;119(8):1970-5. 
3. Liao H, et al. (2023). Cancers. Oct 9;15(19):4900.