Recombinant Mouse TNFRSF13B/CD267 protein (rFc Tag)

Species

Mouse

Purity

>90 %, SDS-PAGE

Tag

rFc Tag

Activity

not tested

Cat no : Eg1814

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Validation Data Gallery

• 

  Purity of Recombinant Mouse TNFRSF13B was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

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Product Information

• Purity: >90 %, SDS-PAGE
• Endotoxin: <0.1 EU/μg protein, LAL method
• Activity:

  Not tested

• Expression: HEK293-derived Mouse TNFRSF13B protein Phe5-Cys128 (Accession# Q9ET35) with a rabbit IgG Fc tag at the C-terminus.
• GeneID: 57916
• Accession: Q9ET35
• PredictedSize: 40.3 kDa
• SDS-PAGE: 40-48 kDa, reducing (R) conditions
• Formulation: Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
• Reconstitution: Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
• Storage Conditions:
  It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
• Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

Tumor necrosis factor receptor superfamily member 13B (TNFRSF13B), also known as CD267 or TACI, is a transmembrane protein of the TNF receptor superfamily found predominantly on B cells. TACI is also expressed on activated T cells, myeloma cells, and expressed by monocytes intracellularly at a low level. TNFRSF13B is a receptor for TNFSF13/APRIL/CD256 and TNFSF13B/BAFF/CD257 and mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-κB and AP-1. It is involved in the stimulation of B- and T-cell function and the regulation of humoral immunity.

References:

1.von Bülow GU, et al. (2000) Mamm Genome. 11(8):628-32.
2.Wang H, et al. (2001) Nat Immunol. 2(7):632-7.
3.Chang SK, et al. (2006) Blood. 108(8):2687-94.
4.Wu Y, et al. (2000) J Biol Chem. 275(45):35478-85.
5.Yu G, et al. (2000) Nat Immunol. 1(3):252-6.
6.von Bülow GU, Bram RJ. (1997) Science. 278(5335):138-41.