NRF2, NFE2L2 Antibody 44 Publications

Rabbit Polyclonal| Catalog number: 16396-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 70 μg/150 μl

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Species specificity:
human, mouse, rat, zebrafish

Positive WB detected in:
DMSO treated HeLa cells

Positive IP detected in:
mouse kidney tissue

Positive IHC detected in:
human ovary tumor tissue, human breast cancer tissue, human colon cancer tissue, human kidney tissue, human liver cancer tissue, human ovary tumor tissue

Positive FC detected in:
MCF-7 cells

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB
IHC : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
nuclear factor (erythroid-derived 2)-like 2

Calculated molecular weight:
605aa,68 kDa

Observed molecular weight:
110, 68 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
NFE2L2

Synonyms
HEBP1, NF E2 related factor 2, NFE2 related factor 2, NFE2L2, NRF2
Background

NRF2, also named as NFE2L2, belongs to the bZIP family and CNC subfamily. It is a transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. NRF2 is important for the coordinated up-regulation of genes in response to oxidative stress. It may be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.Nrf2 is a key player in the regulation of genes encoding for many antioxidative response enzymes.The expression of NRF2 may be induced under oxidative stress (PMID:14567983).In lung cancer, Nrf2 activation in malignant cells has been associated with tumor progression and chemotherapy resistance(PMID:20534738). Identifying patients with abnormal NRF2 expression may be important for selection for chemotherapy in NSCLC. The calculated molecular weight of Nrf2 protein is about 67 kDa, but Nrf2 protein can form a heterodimer with MafG in cell nucleus and molecular weight of heterodimer is 110 kDa.


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