NONO Antibody 7 Publications

Rabbit Polyclonal| Catalog number: 11058-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 48 μg/150 μl

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Species specificity:
human, mouse, rat, bovine

Positive WB detected in:
MCF7 cells, HEK-293 cells, human pancreas tissue, human skeletal muscle tissue, MCF-7 cells, mouse pancreas tissue

Positive IP detected in:
HEK-293 cells

Positive IHC detected in:
human colon cancer tissue

Positive IF detected in:
HepG2 cells

Positive FC detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:20-1:200
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
non-POU domain containing, octamer-binding

Calculated molecular weight:
54 kDa

Observed molecular weight:
54 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
NONO

Synonyms
55 kDa nuclear protein, NONO, NonO protein, NRB54, P54, p54(nrb), P54NRB
Background

Non-pou domain-containing octamer-binding protein(NONO), other named p54nrb, belongs to DBHS family, whose protein are predominately nuclear and involves in transcriptional and posttranscriptional gene regulatory functions as well as DNA repair. This family has roles in a wide range of biological processes, such as the regulation of circadian rhythm, carcinogenesis and progression of cancer. NONO forms heterodimer with SFPQ, and has been implicated in nuclear retention of A- to I-edited RNA as paraspeckle components, pre-mRAN 3'-end formation, cAMP cycling and transcriptional activation.


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