• Featured Product
  • KD/KO Validated

NPTX2 Polyclonal antibody

NPTX2 Polyclonal Antibody for IHC, IP, WB,ELISA

Host / Isotype

Rabbit / IgG


human, mouse, rat





Cat no : 10889-1-AP


NARP, Neuronal pentraxin 2, neuronal pentraxin II, NPTX2

Tested Applications

Positive WB detected inmouse brain tissue, PC-3 cells, SH-SY5Y cells
Positive IP detected inmouse brain tissue
Positive IHC detected inhuman brain tissue, human pancreas cancer tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Recommended dilution

Western Blot (WB)WB : 1:500-1:1000
Immunoprecipitation (IP)IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
Immunohistochemistry (IHC)IHC : 1:50-1:500
Sample-dependent, check data in validation data gallery

Product Information

10889-1-AP targets NPTX2 in WB, IP, IHC, IF, CoIP, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Cited Reactivityhuman, mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen NPTX2 fusion protein Ag1326
Full Name neuronal pentraxin II
Calculated molecular weight 47 kDa
Observed molecular weight 47 kDa
GenBank accession numberBC009924
Gene symbol NPTX2
Gene ID (NCBI) 4885
Conjugate Unconjugated
Form Liquid
Purification Method Antigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

Neuronal pentraxins constitute a family of proteins that are homologous to C-reactive protein (CRP) and serum amyloid P component (SAP), including NPTX1, NPTX2, and the neuronal pentraxin receptor (NPTXR). NPTX2, also known as NARP (neuronal activity-regulated pentaxin), is secreted protein involved in excitatory synapse formation. It also plays a role in clustering of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors at established synapses, resulting in non-apoptotic cell death of dopaminergic nerve cells. NPTX2 is highly up-regulated in the Parkinson's disease (PD), suggesting it may be involved in the pathology of PD. (PMID: 12895424; 17987278; 10748068)


Product Specific Protocols
WB protocol for NPTX2 antibody 10889-1-APDownload protocol
IHC protocol for NPTX2 antibody 10889-1-APDownload protocol
IP protocol for NPTX2 antibody 10889-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols



J Invest Dermatol

NPTX2 Promotes EMT in Cutaneous Squamous Cell Carcinoma via Mettl3-Mediated m6A Methylation of Snail

Authors - Tong Kang


NPTX2 is a key component in the regulation of anxiety.

Authors - Simon Chang
  • KO Validated

Front Immunol

Identification of Neuronal Pentraxins as Synaptic Binding Partners of C1q and the Involvement of NP1 in Synaptic Pruning in Adult Mice.

Authors - Réka Á Kovács

J Neurochem

Quantitative proteomic analysis of the frontal cortex in Alzheimer's disease.

Authors - Gajanan Sathe

J Cancer

Promoter Methylation-Mediated NPTX2 Silencing Promotes Tumor Growth in Human Prostate Cancer.

Authors - Yixi Su

Mol Biol Rep

The neuronal pentraxin II gene (NPTX2) inhibit proliferation and invasion of pancreatic cancer cells in vitro.

Authors - Zhang Ling L


The reviews below have been submitted by verified Proteintech customers who received an incentive forproviding their feedback.


Xin (Verified Customer) (10-10-2022)

Very good with WB to detect endogenous NPTX2 with a clean and clear band with the right MW.

  • Applications: Western Blot
  • Primary Antibody Dilution: 1:3000
  • Cell Tissue Type: mouse brain lysate
NPTX2 Antibody Western Blot validation (1:3000 dilution) in mouse brain lysate (Cat no:10889-1-AP)

Jerome (Verified Customer) (05-07-2019)

This protein should be in the secretory pathway but instead the antibody stains the nucleus

  • Applications: Immunofluorescence,
  • Primary Antibody Dilution: 100
  • Cell Tissue Type: Hela Cells
NPTX2 Antibody Immunofluorescence, validation (100 dilution) in Hela Cells (Cat no:10889-1-AP)