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  • KD/KO Validated

NR1H3 Polyclonal antibody

NR1H3 Polyclonal Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IHC, IF, ELISA

Conjugate

Unconjugated

Cat no : 14351-1-AP

Synonyms

Liver X receptor alpha, LXR a, LXRA, LXRα, NR1H3, Oxysterols receptor LXR alpha, RLD 1



Tested Applications

Positive WB detected inCOLO 320 cells, rat colon tissue, Sp2/0 cells, mouse liver tissue, rat liver tissue

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:2000-1:10000
Sample-dependent, check data in validation data gallery

Product Information

14351-1-AP targets NR1H3 in WB, IHC, IF, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Cited Reactivity human, mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen NR1H3 fusion protein Ag5697
Full Name nuclear receptor subfamily 1, group H, member 3
Calculated molecular weight 50 kDa
Observed molecular weight 45-50 kDa
GenBank accession numberBC041172
Gene symbol NR1H3
Gene ID (NCBI) 10062
Conjugate Unconjugated
Form Liquid
Purification Method Antigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

NR1H3, also known as LXRA, is a liver X receptors, which form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. It's also a ligand-activated LXRs and forms heterodimers with retinoid X receptor, then participates in regulating expression of target genes containing LXR response elements. NR1H3 exists some isoforms with MV 51 kDa and 43-45 kDa.

Protocols

Product Specific Protocols
WB protocol for NR1H3 antibody 14351-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
ratWB

Molecules

Therapeutic Effect of Chitooligosaccharide Tablets on Lipids in High-Fat Diets Induced Hyperlipidemic Rats.

Authors - Di Yang
humanWB,IHC

Cell Death Dis

LXRα promotes cell metastasis by regulating the NLRP3 inflammasome in renal cell carcinoma.

Authors - KeShan Wang
  • KD Validated
humanWB

Br J Pharmacol

Functional interplay between LXR and AMPKα inhibits atherosclerosis in apoE deficient mice - A new anti-atherogenic strategy.

Authors - Chuanrui Ma
humanWB

Biochem Biophys Res Commun

Upregulation of 24(R/S),25-epoxycholesterol and 27-hydroxycholesterol suppresses the proliferation and migration of gastric cancer cells.

Authors - Fenghua Guo
  • KD Validated
mouseWB

Biochim Biophys Acta

DNA topoisomerase II inhibitors induce macrophage ABCA1 expression and cholesterol efflux-an LXR-dependent mechanism.

Authors - Zhang Ling L
humanWB

Cardiovasc Pathol

PMID: 25600616

Authors - Xin Ma

Reviews

The reviews below have been submitted by verified Proteintech customers who received an incentive forproviding their feedback.


FH

K (Verified Customer) (06-10-2021)

works good in rat and human cells form western blotting.

  • Applications: Western Blot
  • Primary Antibody Dilution: 1;1000
  • Cell Tissue Type: rat and human liver cells