NR1H3 Monoclonal antibody

NR1H3 Monoclonal Antibody for IF, WB, ELISA

Host / Isotype

Mouse / IgG1

Reactivity

human, rat, pig and More (1)

Applications

WB, IF, ELISA

Conjugate

Unconjugated

CloneNo.

4A4F7

Cat no : 60134-1-Ig

Synonyms

Liver X receptor alpha, LXR a, LXRA, NR1H3, Oxysterols receptor LXR alpha, RLD 1



Tested Applications

Positive WB detected inT-47D cells, HepG2 cells, MCF-7 cells, COLO 320 cells
Positive IF detected inHepG2 cells

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:2000-1:10000
Immunofluorescence (IF)IF : 1:10-1:100
Sample-dependent, check data in validation data gallery

Published Applications

WBSee 1 publications below

Product Information

60134-1-Ig targets NR1H3 in WB, IF, ELISA applications and shows reactivity with human, rat, pig samples.

Tested Reactivity human, rat, pig
Cited Reactivitymouse
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Immunogen NR1H3 fusion protein Ag6184
Full Name nuclear receptor subfamily 1, group H, member 3
Calculated molecular weight 50 kDa
Observed molecular weight 50 kDa 44 kDa
GenBank accession numberBC041172
Gene symbol NR1H3
Gene ID (NCBI) 10062
Conjugate Unconjugated
Form Liquid
Purification Method Protein G purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

NR1H3, also known as LXRA, is a liver X receptors, which form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. It's also a ligand-activated LXRs and forms heterodimers with retinoid X receptor, then participates in regulating expression of target genes containing LXR response elements.

Protocols

Product Specific Protocols
WB protocol for NR1H3 antibody 60134-1-IgDownload protocol
IF protocol for NR1H3 antibody 60134-1-IgDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
mouseWB

Food Funct

CD36 and DGAT2 facilitate the lipid-lowering effect of chitooligosaccharides via fatty acid intake and triglyceride synthesis signaling.

Authors - Xin Shen