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  • KD/KO Validated

NUP62 Polyclonal antibody

NUP62 Polyclonal Antibody for IP, WB,ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IP, IF, ELISA

Conjugate

Unconjugated

Cat no : 13916-1-AP

Synonyms

62 kDa nucleoporin, IBSN, Nuclear pore glycoprotein p62, nucleoporin 62kDa, Nucleoporin Nup62, NUP62, p62, SNDI



Tested Applications

Positive WB detected inPC-3 cells, NIH/3T3 cells
Positive IP detected inNIH/3T3 cells

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:500-1:3000
Immunoprecipitation (IP)IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
Sample-dependent, check data in validation data gallery

Product Information

13916-1-AP targets NUP62 in WB, IP, IF, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Cited Reactivityhuman, mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen NUP62 fusion protein Ag4912
Full Name nucleoporin 62kDa
Calculated molecular weight 522 aa, 53 kDa
Observed molecular weight 62 kDa
GenBank accession numberBC014842
Gene symbol NUP62
Gene ID (NCBI) 23636
Conjugate Unconjugated
Form Liquid
Purification Method Antigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

NUP62 belongs to the nucleoporin NSP1/NUP62 family. It is essential component of the nuclear pore complex. The N-terminal is probably involved in nucleocytoplasmic transport. The C-terminal is probably involved in protein-protein interaction via coiled-coil formation and may function in anchorage of p62 to the pore complex. Defects in NUP62 are the cause of infantile striatonigral degeneration (SNDI). NUP62 consists of a single promoter with a CpG island and three transcribed exons. It is ubiquitously expressed, an observation compatible with its essential role in transporting cargo across the nuclear envelope. (PMID:16029492)

Protocols

Product Specific Protocols
WB protocol for NUP62 antibody 13916-1-APDownload protocol
IP protocol for NUP62 antibody 13916-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
mouseWB

J Clin Invest

Sec13 promotes oligodendrocyte differentiation and myelin repair through autocrine pleiotrophin signaling.

Authors - Zhixiong Liu
ratWB

Pain

Transcriptional repression of the M channel subunit Kv7.2 in chronic nerve injury.

Authors - Rose Kirstin K
WB

J Biol Chem

O-GlcNAcylation of Thr12 / Ser56 in short form O-GlcNAc transferase (sOGT) regulates its substrate selectivity.

Authors - Li Liu
humanWB,IF

PLoS One

OSBP-related protein 8 (ORP8) regulates plasma and liver tissue lipid levels and interacts with the nucleoporin Nup62.

Authors - Zhou Tianhong T
mouseWB,IF

Exp Cell Res

Silencing of OSBP-related protein 8 (ORP8) modifies the macrophage transcriptome, nucleoporin p62 distribution, and migration capacity.

Authors - Béaslas Olivier O
  • KD Validated
mouseWB

Biochim Biophys Acta

Quantitative proteomics study of host response to virulent and attenuated pseudorabies virus infection in mouse brain.

Authors - Hao-Long Zeng