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OAS1 Polyclonal antibody

OAS1 Polyclonal Antibody for IF, IHC, WB, ELISA

Host / Isotype

Rabbit / IgG


human, mouse, rat





Cat no : 14955-1-AP


(2 5)oligo(A) synthase 1, 2 5 oligoadenylate synthase 1, 2 5A synthase 1, E18/E16, IFI 4, OAS1, OIAS, OIASI, p46/p42 OAS

Tested Applications

Positive WB detected inHeLa cells, mouse brain tissue
Positive IHC detected inhuman liver tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
Positive IF detected inHeLa cells

Recommended dilution

Western Blot (WB)WB : 1:500-1:2000
Immunohistochemistry (IHC)IHC : 1:100-1:400
Immunofluorescence (IF)IF : 1:50-1:500
Sample-dependent, check data in validation data gallery

Product Information

14955-1-AP targets OAS1 in WB, IHC, IF, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Cited Reactivityhuman, mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen OAS1 fusion protein Ag6793
Full Name 2',5'-oligoadenylate synthetase 1, 40/46kDa
Calculated molecular weight 46 kDa
Observed molecular weight 48 kDa
GenBank accession numberBC000562
Gene symbol OAS1
Gene ID (NCBI) 4938
Conjugate Unconjugated
Form Liquid
Purification Method Antigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

The 2-prime,5-prime oligoadenylate synthetases (OASs), such as OAS1, are interferon-induced proteins characterized by their capacity to catalyze the synthesis of 2-prime,5-prime oligomers of adenosine (2-5As). OAS1 (type I enzymes) have molecular weights of 42, 44, 46, and 48 kDa, form tetramers, and contain a single consensus sequence(PMID:12590567). OAS1 is a strong candidate for determining susceptibility or resistance to viral infections(PMID:15732009). This antibody may have weak cross-reaction with OAS3 protein due to the highly homology.


Product Specific Protocols
WB protocol for OAS1 antibody 14955-1-APDownload protocol
IHC protocol for OAS1 antibody 14955-1-APDownload protocol
IF protocol for OAS1 antibody 14955-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols



Acta Biochim Pol

Corylin sensitizes breast cancer cells to overcome tamoxifen resistance by regulating OAS1/miR-22-3p/SIRT1 axis.

Authors - Li Che


Anti-inflammatory Properties of the Alpha-Melanocyte-Stimulating Hormone in Models of Granulomatous Inflammation.

Authors - Abdolrazagh Hashemi Shahraki

Arch Virol

Myxovirus resistance protein A inhibits hepatitis C virus replication through JAK-STAT pathway activation.

Authors - Hailong Wang


Synthesis of potent antagonists of receptors for growth hormone-releasing hormone with antitumor and anti-inflammatory activity.

Authors - Renzhi Cai

Front Med (Lausanne)

Single-Cell RNA Sequencing Reveals Cellular and Transcriptional Changes Associated With M1 Macrophage Polarization in Hidradenitis Suppurativa

Authors - Paula Mariottoni

Int J Mol Sci

STAT3 Regulates the Type I IFN-Mediated Antiviral Response by Interfering with the Nuclear Entry of STAT1.

Authors - Huanru Wang


The reviews below have been submitted by verified Proteintech customers who received an incentive forproviding their feedback.


Seong (Verified Customer) (11-27-2018)

OAS1 polyclonal antibody (14955-1-AP) did work by Western Blot (1:1,500) of ARPE-19 cells induced with interferon gamma but the band was very weak in uninduced cells.

  • Applications: Western Blot,
  • Primary Antibody Dilution: 1:1,500
  • Cell Tissue Type: human ARPE-19 cells