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PAX6 antibody (pAb)

Host / Isotype

Rabbit / IgG

Reactivity

Human

Applications

WB

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Cat No : 61611,61612 61611

Synonyms

PAX6, Paired Box 6, AN, AN2, D11S812E, Aniridia Type II Protein,WAGR, MGDA, oculorhombin, aniridia, Paired Box Homeotic Gene-6, keratitis, Paired Box Protein -6, Paired Box Gene 6 (Aniridia, Keratitis), Oculorhombin, pancreas, pax4, regulates, gene transcription, peter’s anomaly, antibody, antibodies, polyclonal, pab, western blotting, wb, sample

Validation Data Gallery

  • PAX6 antibody (pAb) tested by Western blot. Detection of PAX6 by Western blot. The analysis was performed using 30 ug HEK293 nuclear extract and PAX6 (pAb) at a 1:500 dilution.

    PAX6 antibody (pAb) tested by Western blot. Detection of PAX6 by Western blot. The analysis was performed using 30 ug HEK293 nuclear extract and PAX6 (pAb) at a 1:500 dilution.

Product Information

Tested Applications WB

Applications Validated by Active Motif: WB*: 1:500 - 1:1,000 dilution *Note: many chromatin-bound proteins are not soluble in a low salt nuclear extract and fractionate to the pellet. Therefore, we recommend a High Salt / Sonication Protocol when preparing nuclear extracts for Western blot.
Tested Reactivity Human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen This antibody was raised against a peptide within the C-terminal region of human PAX6.
Full Name PAX6 antibody (pAb)
Synonyms PAX6, Paired Box 6, AN, AN2, D11S812E, Aniridia Type II Protein,WAGR, MGDA, oculorhombin, aniridia, Paired Box Homeotic Gene-6, keratitis, Paired Box Protein -6, Paired Box Gene 6 (Aniridia, Keratitis), Oculorhombin, pancreas, pax4, regulates, gene transcription, peter’s anomaly, antibody, antibodies, polyclonal, pab, western blotting, wb, sample
Molecular weight 52 kDa
GenBank accession numberNP_001595
RRIDAB_2793701
Purification Method Affinity Purified
Buffer Purified IgG in PBS with 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic.
Storage Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Background Information

PAX6 (Paired Box 6) is a transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes.