|Positive WB detected in||mouse heart tissue, HepG2 cells, RAW 264.7 cells|
|Western Blot (WB)||WB : 1:200-1:1000|
|Sample-dependent, check data in validation data gallery|
The immunogen of 18251-1-AP is PD-L2/CD273 Fusion Protein expressed in E. coli.
|Tested Reactivity||human, mouse, rat|
|Cited Reactivity||human, mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||PD-L2/CD273 fusion protein Ag13039|
|Full Name||programmed cell death 1 ligand 2|
|Calculated molecular weight||273 aa, 31 kDa|
|Observed molecular weight||42 kDa, 28 kDa|
|GenBank accession number||BC074766|
|Gene ID (NCBI)||80380|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
Programmed cell death ligand 2 (PD-L2, also known as CD273, or B7-DC), is one of the B7 family molecules which are type I transmembrane proteins belonging to the immunoglobulin superfamily. PD-L2 was identified both by its homology to PD-L1 and by analysis of genes differentially expressed in libraries generated from dendritic cells (DC) and activated macrophages (PMID: 14515254). PD-L2 is a second ligand for PD-1, a costimulatory molecule that plays an inhibitory role in regulating T cell activation in the periphery.
Targeting amphiregulin (AREG) derived from senescent stromal cells diminishes cancer resistance and averts programmed cell death 1 ligand (PD-L1)-mediated immunosuppression.
ANO9 regulates PD-L2 expression and binding ability to PD-1 in gastric cancer.
J Cell Mol Med
IFI30 expression is an independent unfavourable prognostic factor in glioma.
J Transl Med
Treatment with eFT-508 increases chemosensitivity in breast cancer cells by modulating the tumor microenvironment.
Differential expression of PD‑L1 and PD‑L2 is associated with the tumor microenvironment of TILs and M2 TAMs and tumor differentiation in non‑small cell lung cancer.
Programmed death-ligand 2 (PD-L2) expression in bladder cancer.