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PDX1 antibody (pAb)

Host / Isotype

Rabbit / IgG

Reactivity

Human

Applications

WB

Activ Motif logo

Cat No : 61289,61290 61289

Synonyms

PDX1, pancreatic and duodenal homeobox 1, insulin promoter factor 1, homeodomain transcription factor, pancreatic-duodenal homeobox factor 1, Glucose-sensitive factor, GSF, IPF1, IUF1, IDX-1, MODY4, PDX-1, STF-1, antibody, polyclonal, pAb, sample, western blotting

Validation Data Gallery

  • PDX1 antibody (pAb) tested by Western blot. PDX1 detection by Western blot. The analysis was performed using 30 ug Caco-2 nuclear cell extract and PDX1 at a 1:500 dilution.

    PDX1 antibody (pAb) tested by Western blot. PDX1 detection by Western blot. The analysis was performed using 30 ug Caco-2 nuclear cell extract and PDX1 at a 1:500 dilution.

Product Information

Tested Applications WB

Applications Validated by Active Motif: WB: 1:500 - 1:1,000 dilution
Tested Reactivity Human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen This PDX1 antibody was raised against a peptide within the N-terminal region of human PDX1.
Full Name PDX1 antibody (pAb)
Synonyms PDX1, pancreatic and duodenal homeobox 1, insulin promoter factor 1, homeodomain transcription factor, pancreatic-duodenal homeobox factor 1, Glucose-sensitive factor, GSF, IPF1, IUF1, IDX-1, MODY4, PDX-1, STF-1, antibody, polyclonal, pAb, sample, western blotting
Molecular weight 42 kDa
GenBank accession numberNP_000200
RRIDAB_2793583
Purification Method Affinity Purified
Buffer Purified IgG in PBS with 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic.
Storage Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Background Information

PDX1 (pancreatic and duodenal homeobox 1, GSF, IPF1, IUF1, IDX-1, MODY4, PDX-1, STF-1) activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell.