Phospho-Tau (Thr181) Polyclonal antibody
Phospho-Tau (Thr181) Polyclonal Antibody for WB, ELISA
Host / Isotype
Rabbit / IgG
Human, mouse and More (1)
WB, IF, ELISA
Cat no : 28866-1-AP
|Positive WB detected in||PDGF treated SH-SY5Y cells|
|Western Blot (WB)||WB : 1:500-1:1000|
|Sample-dependent, check data in validation data gallery|
28866-1-AP targets Phospho-Tau (Thr181) in WB, IF, ELISA applications and shows reactivity with Human, mouse samples.
|Tested Reactivity||Human, mouse|
|Cited Reactivity||human, mouse|
|Host / Isotype||Rabbit / IgG|
|Full Name||microtubule-associated protein tau|
|Calculated molecular weight||37-46, 79-81 kDa|
|Observed molecular weight||50 kDa|
|GenBank accession number||BC000558|
|Gene ID (NCBI)||4137|
|Purification Method||Protein A purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.|
Tau (tubulin-associated unit) is a microtubule-associated protein (also known as MAPT), expressed mainly in neurons of the central nervous system. Its primary function is to modulate microtubule dynamics for maintaining axonal cytoskeleton. The Tau protein has six isoforms produced from a single gene through alternative RNA splicing. Isoforms differ in number of inserts at the N-terminal half and the number of repeats at the C-terminal half (3 repeat-3R; 4 repeat-4R). Tau is hyperphosphorylated during aging and in age-related neurodegenerative diseases such as Alzheimer's disease (AD) and fronto-temporal dementia. Hyperphosphorylation of Tau leads to the formation of neurofibrillary tangles (NFT) in the neurons and glia cells, which is one of the hallmarks of AD.
|Product Specific Protocols|
|WB protocol for Phospho-Tau (Thr181) antibody 28866-1-AP||Download protocol|
|Click here to view our Standard Protocols|
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