RAB27B Antibody 9 Publications

Rabbit Polyclonal| Catalog number: 13412-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 40 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
rat spleen tissue, A375 cells, DU 145 cells, MCF-7 cells, PC-3 cells

Positive IHC detected in:
human pancreas cancer tissue, human breast cancer tissue, human colon cancer tissue, human liver cancer tissue, human pancreas cancer tissue, human prostate cancer tissue, human testis tissue

Positive IF detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:50-1:500
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
RAB27B, member RAS oncogene family

Calculated molecular weight:
218aa,25 kDa

Observed molecular weight:
25-30 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
RAB27B

Synonyms
C25KG, RAB27B, Ras related protein Rab 27B
Background

The Rab27 GTPase subfamily consists of two closely related homologs, Rab27a and Rab27b. Northern blot analysis revealed that Rab27b is expressed significantly only in testis, in which the predominant transcript was 1.4 kb in size. An 8-kb mRNA of unknown origin was detected in many tissues. Rab27b is associated with tubulovesicle membranes in the parietal cell and Rab27b may play a role in stimulation-associated membrane recruitment and gastric acid secretion. Rab27b is recently reported as a marker for breast cancer progression. It regulates invasive growth and metastasis in ER-positive breast cancer cell lines, and increased expression is associated with poor prognosis in humans.


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