- Featured Product
- KD/KO Validated
RACK1; GNB2L1 Polyclonal antibody
RACK1; GNB2L1 Polyclonal Antibody for IHC, WB, ELISA
Cat no : 27592-1-AP
|Positive WB detected in
|mouse liver tissue, L02 cells, HepG2 cells, rat liver tissue
|Positive IHC detected in
|human liver cancer tissue, human stomach cancer tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
|Western Blot (WB)
|WB : 1:500-1:3000
|IHC : 1:400-1:1600
|It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
|Sample-dependent, check data in validation data gallery
27592-1-AP targets RACK1; GNB2L1 in WB, RIP, IP, IHC, IF, CoIP, ELISA applications and shows reactivity with Human, mouse, rat samples.
|Human, mouse, rat
|human, mouse, monkey, pig
|Host / Isotype
|Rabbit / IgG
|RACK1; GNB2L1 fusion protein Ag26708
|guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
|Calculated molecular weight
|Observed molecular weight
|GenBank accession number
|Gene ID (NCBI)
|Antigen affinity purification
|PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
|Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.
Members of the protein kinase C (PKC) family play a key regulatory role in a variety of cellular functions, including cell growth and differentiation, gene expression, hormone secretion and membrane function. RACK1 (receptor for activated protein kinase C 1), encoded by GNB2L1 gene, is a 317 amino acid guanine nucleotide-binding protein subunit beta-2-like 1 protein which is involved in the recruitment, assembly and/or regulation of a variety of signaling molecules, it contains 7 WD-repeats and is implicated in various protein interaction activities. RACK1 is a component of the 40S ribosomal subunit involved in translational repression. Recent finding suggests that RACK1 may be a new promising diagnosis biomarker and therapeutic target for non-small-cell lung cancer (NSCLC).
J Clin Invest
CAP2 promotes gastric cancer metastasis by mediating the interaction between tumor cells and tumor-associated macrophages
The matrix protein of respiratory syncytial virus suppresses interferon signaling via RACK1 association
RACK1 promotes porcine reproductive and respiratory syndrome virus infection in Marc-145 cells through ERK1/2 activation
Ann Transl Med
USP41 promotes breast cancer via regulating RACK1.
Small molecule screening identified cepharanthine as an inhibitor of porcine reproductive and respiratory syndrome virus infection in vitro by suppressing integrins/ILK/RACK1/PKCα/NF-κB signalling axis.
Inhibition of porcine reproductive and respiratory syndrome virus by PKC inhibitor dequalinium chloride in vitro.