RAP1GAP Recombinant antibody, PBS Only

RAP1GAP Uni-rAbTM Recombinant Antibody for WB, Indirect ELISA
Cat No. 86011-2-PBS
Clone No.250422E11

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, Indirect ELISA

KIAA0474, RAP1 GTPase activating protein, Rap1 GTPase-activating protein 1, RAP1GA1, RAP1GAP1

Formulation:  PBS Only
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

Freight/Packing: -

Quantity

Please visit your regions distributor:


Product Information

86011-2-PBS targets RAP1GAP in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen RAP1GAP fusion protein Ag5576 Predict reactive species
Full Name RAP1 GTPase activating protein
Calculated Molecular Weight 73 kDa
Observed Molecular Weight 85-95 kDa
GenBank Accession NumberBC054490
Gene Symbol RAP1GAP
Gene ID (NCBI) 5909
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDP47736
Storage Buffer PBS only, pH 7.3.
Storage ConditionsStore at -80°C.

Background Information

Rap1 GTPase-activating protein (Rap1GAP) is an important tumor suppressor. Rap1GAP was associated with the AMPK and NF-κB signaling pathways and that Rap1GAP inhibited AMPK/SIRT1 and activated the NF-κB signaling pathway in model animals. Rap1GAP was verified to regulate the AMPK SIRT1/NF-κB signaling pathway and exacerbate the damage to myocardial cells caused by ischemia and hypoxia (PMID: 38320624). Rap1GAP is involved in Ang II-induced cardiomyocyte hypertrophy through the regulation of autophagy (PMID: 33936386). Rap1GAP, which is the GTPase-activating protein of Rap1, can bind to Rap1, promote the transformation of GTP from its active to inactive form, and terminate signal transduction (PMID: 21295042).

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