RPL23 Antibody 3 Publications

Rabbit Polyclonal| Catalog number: 16086-1-AP

  • Print page
  • Download PDF
  • Live Chat

-_-

Freight/Packing

Size: 09µ/gram

Please visit your regions distributor:



Species specificity:
Human, Mouse, Rat

Positive WB detected in:
HeLa cells, PC-3 cells

Positive IHC detected in:
human brain tissue

Recommended dilution:
WB : 1:200-1:2000
IHC : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
ribosomal protein L23

Calculated molecular weight:
140aa,15 kDa

Observed molecular weight:
15 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
RPL23

Synonyms
60S ribosomal protein L17, 60S ribosomal protein L23, ribosomal protein L23, rpL17, RPL23
Background

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins [PMID:9582194]. RPL23 is a component of the 60 S large ribosomal subunit that interacts functionally with murine double minute 2 protein (MDM2 or HDM2 in humans). Upon binding to MDM2, RPL23 inhibits MDM2-mediated p53 degradation, thus activating p53 and inducing cellular apoptosis [PMID:15314174]. Intriguingly, RPL23 has also been suggested to be a negative regulator of apoptosis by suppressing the Miz1-induced transcription of the cell cycle inhibitors p15INK4B and p21CIP1[PMID:19160485].


Back
to top