RPL23 Antibody 4 Publications

Rabbit Polyclonal| Catalog number: 16086-1-AP

Featured Product KD/KO validated

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Con: 50 μg/150μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
HeLa cells, PC-3 cells

Positive IHC detected in:
human brain tissue

Recommended dilution:
WB : 1:200-1:2000
IHC : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
ribosomal protein L23

Calculated molecular weight:
140aa,15 kDa

Observed molecular weight:
15 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
RPL23

Synonyms
60S ribosomal protein L17, 60S ribosomal protein L23, ribosomal protein L23, rpL17, RPL23
Background

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins [PMID:9582194]. RPL23 is a component of the 60 S large ribosomal subunit that interacts functionally with murine double minute 2 protein (MDM2 or HDM2 in humans). Upon binding to MDM2, RPL23 inhibits MDM2-mediated p53 degradation, thus activating p53 and inducing cellular apoptosis [PMID:15314174]. Intriguingly, RPL23 has also been suggested to be a negative regulator of apoptosis by suppressing the Miz1-induced transcription of the cell cycle inhibitors p15INK4B and p21CIP1[PMID:19160485].


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