RYR2 Polyclonal antibody

RYR2 Polyclonal Antibody for IF, IHC, WB,ELISA

Host / Isotype

Rabbit / IgG


human, mouse and More (1)





Cat no : 19765-1-AP


ARVC2, ARVD2, ryanodine receptor 2 (cardiac), ryanodine receptor 2, cardiac, RYR2, VTSIP

Tested Applications

Positive WB detected inHeLa cells, human brain tissue, human placenta tissue, mouse brain tissue
Positive IHC detected inhuman heart tissue, human brain tissue, human placenta tissue, human skeletal muscle tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
Positive IF detected inmouse heart tissue, HEK-293 cells

Recommended dilution

Western Blot (WB)WB : 1:500-1:2000
Immunohistochemistry (IHC)IHC : 1:100-1:400
Immunofluorescence (IF)IF : 1:50-1:500
Sample-dependent, check data in validation data gallery

Product Information

19765-1-AP targets RYR2 in WB, IHC, IF applications and shows reactivity with human, mouse samples.

Tested Reactivity human, mouse
Cited Reactivity human, mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen Peptide
Full Name ryanodine receptor 2 (cardiac)
Calculated molecular weight 565 kDa
Observed molecular weight 250 kDa
GenBank accession numberNM_001035
Gene symbol RYR2
Gene ID (NCBI) 6262
Conjugate Unconjugated
Form Liquid
Purification Method Antigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

RYR2 belongs to the ryanodine receptor family. RYR2 provides communication between transverse-tubules and sarcoplasmic reticulum. Contraction of cardiac muscle is triggered by release of calcium ions from SR following depolarization of T-tubules. Defects in RYR2 are the cause of familial arrhythmogenic right ventricular dysplasia type 2 (ARVD2) which known as arrhythmogenic right ventricular cardiomyopathy 2 (ARVC2). Defects in RYR2 are the cause of catecholaminergic polymorphic ventricular tachycardia type 1 (CPVT1) which known as stress-induced polymorphic ventricular tachycardia (VTSIP). This antibody detects a band at ~250 kDa which has been reported (PMID: 22962011).


Product Specific Protocols
WB protocol for RYR2 antibody 19765-1-APDownload protocol
IHC protocol for RYR2 antibody 19765-1-APDownload protocol
IF protocol for RYR2 antibody 19765-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols



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