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  • KD/KO Validated

SESN3 Polyclonal antibody

SESN3 Polyclonal Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG


human, mouse, rat





Cat no : 11431-2-AP


SESN3, SEST3, sestrin 3

Tested Applications

Positive WB detected inHeLa cells, A431 cells, A549 cells, HEK-293 cells, HepG2 cells, mouse liver tissue, mouse ovary tissue

Recommended dilution

Western Blot (WB)WB : 1:500-1:1000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

11431-2-AP targets SESN3 in WB, IHC, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Cited Reactivityhuman, mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen SESN3 fusion protein Ag1961
Full Name sestrin 3
Calculated Molecular Weight 492 aa, 57 kDa
Observed Molecular Weight 36 kDa, 51-59 kDa
GenBank Accession NumberBC017296
Gene Symbol SESN3
Gene ID (NCBI) 143686
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

Sestrins, including sestrin-1 (PA26), sestrin-2 (Hi95), and sestrin-3, are 48 to 65 kDa cystein sulfinyl reductases and they modulate peroxide signaling and antioxidant defense. These proteins selectively reduce or repair hyperoxidized forms of typical 2-Cys peroxiredoxins within eukaryotes. Expression of these proteins is regulated by p53, a tumor suppressor protein. Sestrin 3 was identified as a forkhead box O (FoxO) target gene with antioxidant activity. Recently it was reported that sestrin 3 may play an important role in AKT induced increase in ROS and it might be a promising target in selectively killing cancer cells containing high levels of AKT activity.


Product Specific Protocols
WB protocol for SESN3 antibody 11431-2-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols



Dev Cell

FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor.

Authors - Chia-Chen Chen
  • KD Validated

Proc Natl Acad Sci U S A

FOXO1 and FOXO3 transcription factors have unique functions in meniscus development and homeostasis during aging and osteoarthritis.

Authors - Kwang Il Lee


Selective eradication of cancer displaying hyperactive Akt by exploiting the metabolic consequences of Akt activation.

Authors - Veronique Nogueira
  • KD Validated

Biochim Biophys Acta Mol Basis Dis

Exercise ameliorates chronic inflammatory response induced by high-fat diet via Sestrin2 in an Nrf2-dependent manner

Authors - Sujuan Liu

Osteoarthritis Cartilage

Suppression of Sestrins in aging and osteoarthritic cartilage: dysfunction of an important stress defense mechanism.

Authors - T Shen

PLoS One

Regulatory Effects of Sestrin 3 (SESN3) in BCR-ABL Expressing Cells.

Authors - Vakana Eliza E