SIRT3 Antibody 7 Publications

Rabbit Polyclonal| Catalog number: 10099-1-AP

Featured Product KD/KO validated

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Con: 25 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
mouse liver tissue, human spleen tissue, mouse kidney tissue, mouse skeletal muscle tissue

Recommended dilution:
WB : 1:200-1:1000

Product Information


Purification method:
Antigen affinity purification


PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information

Full name:
sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae)

Calculated molecular weight:
44 kDa

Observed molecular weight:
28 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol

hSIRT3, SIR2 like protein 3, SIR2L3, SIRT3

Sirtuins are NAD+-dependent histone/protein deacetylases (HDAC) and SIRT3 is the only sirtuin whose increased expression has been shown to correlate with an extended life span in humans. It is localized in the mitochondrial matrix, where it regulates the acetylation levels of metabolic enzymes, including acetyl coenzyme A synthetase 2. SIRT3 is stress-responsive and its increased expression protects myocytes from genotoxic and oxidative stress-mediated cell death. full-length hSIRT3 (44 kDa) is an inert protein and that it is activated inside the mitochondria following deletion of 142 amino acids of the N-terminal segment. This processed form of SIRT3 is approximately 28 kDa and possesses deacetylase activity. The full SIRT3 is a 44 kDa protein and is processed by mitochondrial processing peptidase (MPP) to give a 28 kDa product.

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