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SIRT6 Antibody 2 Publications

Rabbit Polyclonal| Catalog number: 13572-1-AP

Featured Product KD/KO validated

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Con: 43 μg/150 μl

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Tested Applications
Applications:
ELISA, WB, IHC, IF
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13572-1-AP;human brain tissue

human brain tissue were subjected to SDS PAGE followed by western blot with 13572-1-AP(SIRT6 antibody) at dilution of 1:400 incubated at room temperature for 1.5 hours

13572-1-AP;human brain tissue

Immunohistochemical of paraffin-embedded human brain using 13572-1-AP(SIRT6 antibody) at dilution of 1:50 (under 10x lens)

13572-1-AP;human brain tissue

Immunohistochemical of paraffin-embedded human brain using 13572-1-AP(SIRT6 antibody) at dilution of 1:50 (under 40x lens)

Species specificity:
human, mouse, rat
Positive WB detected in:
human brain tissue, HeLa cells
Positive IHC detected in:
human brain tissue
Recommended dilution:
WB : 1:500-1:1000
IHC : 1:50-1:200

Product Information

Source:
Rabbit
Purification method:
Antigen affinity purification
Isotype:
IgG
Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information

Immunogen:
SIRT6 fusion protein ag4469
Full name:
sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae)
Calculated molecular weight:
328aa,36 kDa
Observed molecular weight:
45-50 kDa
GenBank accession number:
BC028220
Gene ID (NCBI):
51548
Gene symbol
SIRT6
Synonyms
SIR2 like protein 6, SIR2L6, SIRT6
Background

SIRT6, also named as SIR2L6, belongs to the sirtuin family. It is known to deacetylate H3K9, H3K56 and CtIP in vivo. SIRT6 regulates the expression of a large number of stress-responsive and metabolism related genes, promotes genomic stability and stimulates base excision and double strand break DNA repair(PMID: 20729089). By maintaining both the integrity and the expression of the mammalian genome, SIRT6 thus serves several roles that parallel Sir2 function(PMID: 20729089). In addtion, Sirt6-deficient animals develop normally for several weeks after birth, but succumb to an acute multi-organ degenerative syndrome that is uniformly lethal by one month of age(PMID: 19135889). This antibody is a rabbit polyclonal antibody raised against full length human SIRT6 antigen.


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