SIRT6 Monoclonal antibody

SIRT6 Monoclonal Antibody for WB, ELISA

Host / Isotype

Mouse / IgG1


Human, mouse







Cat no : 67510-1-Ig


SIR2 like protein 6, SIR2L6, SIRT6

Tested Applications

Positive WB detected inJAR cells, NCCIT cells, LNCaP cells, HeLa cells, Jurkat cells, K-562 cells, HL-60 cells.

Recommended dilution

Western Blot (WB)WB : 1:2000-1:10000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

67510-1-Ig targets SIRT6 in WB, IF, CoIP, ELISA applications and shows reactivity with Human, mouse samples.

Tested Reactivity Human, mouse
Cited Reactivitymouse
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Immunogen SIRT6 fusion protein Ag24103
Full Name sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae)
Calculated Molecular Weight 39 kDa
Observed Molecular Weight 40 kDa
GenBank Accession NumberBC028220
Gene Symbol SIRT6
Gene ID (NCBI) 51548
Conjugate Unconjugated
Form Liquid
Purification MethodProtein G purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

SIRT6, also named as SIR2L6, belongs to the sirtuin family. It is known to deacetylate H3K9, H3K56 and CtIP in vivo. SIRT6 regulates the expression of a large number of stress-responsive and metabolism related genes, promotes genomic stability and stimulates base excision and double strand break DNA repair(PMID: 20729089). By maintaining both the integrity and the expression of the mammalian genome, SIRT6 thus serves several roles that parallel Sir2 function(PMID: 20729089). In addtion, Sirt6-deficient animals develop normally for several weeks after birth, but succumb to an acute multi-organ degenerative syndrome that is uniformly lethal by one month of age(PMID: 19135889).


Product Specific Protocols
WB protocol for SIRT6 antibody 67510-1-IgDownload protocol
Standard Protocols
Click here to view our Standard Protocols



Cell Prolif

20-HETE synthesis inhibition attenuates traumatic brain injury-induced mitochondrial dysfunction and neuronal apoptosis via the SIRT1/PGC-1α pathway: A translational study.

Authors - Wenxing Cui

ACS Omega

Harnessing the Therapeutic Potential of Ginsenoside Rd for Activating SIRT6 in Treating a Mouse Model of Nonalcoholic Fatty Liver Disease

Authors - Tianqi Cui

Mol Med

Microglia Sirt6 modulates the transcriptional activity of NRF2 to ameliorate high-fat diet-induced obesity

Authors - Xiaoxia Xiao

J Orthop Res

Orientin inhibits inflammation in chondrocytes and attenuates osteoarthritis through Nrf2/NF-κB and SIRT6/NF-κB pathway

Authors - Weiyi Xia