|Positive WB detected in||JAR cells, NCCIT cells, HT-29 cells|
|Western Blot (WB)||WB : 1:2000-1:10000|
|Sample-dependent, check data in validation data gallery|
67510-1-Ig targets SIRT6 in WB,ELISA applications and shows reactivity with Human, mouse samples.
|Tested Reactivity||Human, mouse|
|Host / Isotype||Mouse / IgG1|
|Immunogen||SIRT6 fusion protein Ag24103|
|Full Name||sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae)|
|Calculated molecular weight||39 kDa|
|Observed molecular weight||40 kDa|
|GenBank accession number||BC028220|
|Gene ID (NCBI)||51548|
|Purification Method||Protein G purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Aliquoting is unnecessary for -20oC storage.|
SIRT6, also named as SIR2L6, belongs to the sirtuin family. It is known to deacetylate H3K9, H3K56 and CtIP in vivo. SIRT6 regulates the expression of a large number of stress-responsive and metabolism related genes, promotes genomic stability and stimulates base excision and double strand break DNA repair(PMID: 20729089). By maintaining both the integrity and the expression of the mammalian genome, SIRT6 thus serves several roles that parallel Sir2 function(PMID: 20729089). In addtion, Sirt6-deficient animals develop normally for several weeks after birth, but succumb to an acute multi-organ degenerative syndrome that is uniformly lethal by one month of age(PMID: 19135889).