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SIX2 Antibody 140 Publications

Rabbit Polyclonal| Catalog number: 11562-1-AP

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Con: 78 μg/150 μl

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Tested Applications

Applications:
WB, pull-down, IP, chIP, ELISA
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Images See all

SIX2 Antibody WB HEK-293 cells 11562-1-AP

Various lysates were subjected to SDS PAGE followed by western blot with 11562-1-AP (SIX2 antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours

SIX2 Antibody IP HEK-293 cells 11562-1-AP

IP Result of anti-SIX2 (IP:11562-1-AP, 3ug; Detection:11562-1-AP 1:500) with HEK-293 cells lysate 2700ug.

SIX2 Antibody IF heritable frontonasal dysplasia and renal hypoplasia in 3H1 Br mice 11562-1-AP

IF result from Fogelgren B, PMID:18570229, "Misexpression of Six2 is associated with heritable frontonasal dysplasia and renal hypoplasia in 3H1 Br mice."

Species specificity:
human, mouse, rat, American alligator, pig, swine
Positive WB detected in:
HEK-293 cells, PC-3 cells, L02 cells
Positive IP detected in:
HEK-293 cells
Recommended dilution:
WB : 1:500-1:3000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
Sample-dependent, check data in Validation tab

Product Information

Source:
Rabbit
Purification method:
Antigen affinity purification
Isotype:
IgG
Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information

Immunogen:
SIX2 fusion protein Ag2124
Full name:
SIX homeobox 2
Calculated molecular weight:
291aa,32 kDa
Observed molecular weight:
32-37 kDa
GenBank accession number:
BC024033
Gene ID (NCBI):
10736
Gene symbol
SIX2
Synonyms
Homeobox protein SIX2, Sine oculis homeobox homolog 2, SIX homeobox 2, SIX2

Background

The SIX proteins (sine oculis) are a family of homeodomain transcription factors that share a conserved DNA binding domain. Six members (Six1-Six6) of the Six gene family have been identified in mice and humans. SIX2, containing one homeobox DNA-binding domain, is highly expressed in fetal tissues but expression is limited in adult tissues. SIX2 may be involved in limb tendon and ligament development[PMID:21420949]. It has been previously shown that SIX2 is expressed in developing mesenchymal tissue including head and urogenital system at the time of overt midfacial and renal differentiation[PMID: 22282599]. This antibody is a rabbit polyclonal antibody raised against full length SIX2 of human origin.


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