SMCR7L/MID51 Antibody 17 Publications

Rabbit Polyclonal| Catalog number: 20164-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 36 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
HT-1080 cells, mouse heart tissue, mouse testis tissue, NIH/3T3 cells, rat liver tissue, rat testis tissue

Positive IP detected in:
RAW 264.7 cells

Positive IF detected in:
Hela cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
Smith-Magenis syndrome chromosome region, candidate 7-like

Calculated molecular weight:
463aa,51 kDa

Observed molecular weight:
48-51 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
SMCR7L

Synonyms
dJ1104E15.3, FLJ20232, HSU79252, MID51, MIEF1, SMCR7L
Background

Human SMCR7L gene encodes, MID51, the mitochondrial dynamic protein of 51 kDa (also called mitochondrial elongation factor 1, MIEF1). MID51 is a single-pass membrane protein anchored to the mitochondrial outer membrane and regulates mitochondrial morphology. Mitochondrial morphology is controlled by two opposing processes: fusion and fission. Elevated MID51 levels induce extensive mitochondrial fusion, whereas depletion of MID51 causes mitochondrial fragmentation. MID51 interacts with and recruits Drp1 to mitochondria, suggesting a critical role of MID51 in regulation of mitochondrial fusion-fission machinery in vertebrates.


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