TAP1 Antibody 8 Publications

Rabbit Polyclonal| Catalog number: 11114-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 36 μg/150 μl

Choose size:

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Species specificity:
human, mouse, rat

Positive WB detected in:
HepG2 cells, human skeletal muscle tissue, mouse skeletal muscle tissue, mouse spleen tissue, Raji cells

Positive IP detected in:
HepG2 cells

Positive IHC detected in:
human pancreas cancer tissue, human lung cancer tissue, human pancreas cancer tissue

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:20-1:200
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)

Calculated molecular weight:
81 kDa

Observed molecular weight:
70-81 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
TAP1

Synonyms
ABCB2, Antigen peptide transporter 1, PSF 1, RING 4, RING4, TAP1
Background

TAP1, also known as ABCB2, PSF1 or RING4, is a member of the ATP-binding cassette (ABC) family of transmembrane transporters and is an essential component of the major histocompatability complex (MHC) class I antigen-presenting pathway. TAP is involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. It also acts as a molecular scaffold for the final stage of MHC class I folding. Defects in TAP1 are a cause of bare lymphocyte syndrome type 1 (BLS1). Western blot analysis using this antibody detected a major band around 70-80kD in HeLa cells.


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