TBC1D2 Polyclonal antibody

TBC1D2 Polyclonal Antibody for ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

ELISA

Conjugate

Unconjugated

Cat no : 13251-1-AP

Synonyms

Armus, PARIS 1, PARIS1, PP8997, TBC1 domain family member 2A, TBC1 domain family, member 2, TBC1D2, TBC1D2A



Tested Applications

Recommended dilution

ApplicationDilution
Sample-dependent, check data in validation data gallery

Product Information

13251-1-AP targets TBC1D2 in ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen TBC1D2 fusion protein Ag3954
Full Name TBC1 domain family, member 2
Calculated molecular weight 917 aa, 104 kDa
GenBank accession numberBC028918
Gene symbol TBC1D2
Gene ID (NCBI) 55357
Conjugate Unconjugated
Form Liquid
Purification Method Antigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

TBC1D2, also known as Armus, acts as GTPase-activating protein for RAB7A, a Rab required for lysosome function. Armus is also an effector of Rac1, a small GTPase that regulates cytoskeletal remodeling, migration, and adhesion events. Upon epidermal growth factor (EGF) treatment, Armus regulates E-cadherin degradation during cell scattering but has no effect on cadherin levels at steady state. Armus mediates a crosstalk between Rac1 activation and Rab7 cycling and thus coordinates the function of these two small GTPases during cell scattering. Recently, Armus is found to play an important role in regulating autophagy.