TDO2 Recombinant antibody, PBS Only

• 

  WB analysis of rat liver using 83236-2-RR (same clone as 83236-2-PBS)

  rat liver tissue were subjected to SDS PAGE followed by western blot with 83236-2-RR (TDO2 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 83236-2-PBS in a different storage buffer formulation.

• 

  Affinity and Kinetic Characterization of 83236-2-RR

  Biolayer interferometry (BLl) kinetic assays of 83236-2-RR against Human TDO2 were performed. The affinity constant is below 1 pM.

TDO2 Uni-rAb^TM Recombinant Antibody for WB, Cytometric bead array, Indirect ELISA

Cat No. 83236-2-PBS

Clone No.240068C2

Host / Isotype

Rabbit / IgG

Reactivity

human, rat

Applications

WB, Cytometric bead array, Indirect ELISA

Synonyms

240068C2, EC:1.13.11.11, TDO, TO, TPH2

---

Product Information

83236-2-PBS targets TDO2 in WB, Cytometric bead array, Indirect ELISA applications and shows reactivity with human, rat samples.

• Tested Reactivity: human, rat
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen: TDO2 fusion protein Ag8531
• Full Name: tryptophan 2,3-dioxygenase
• Calculated Molecular Weight: 406 aa, 48 kDa
• Observed Molecular Weight: 40-50 kDa
• GenBank Accession Number: BC005355
• Gene Symbol: TDO2
• Gene ID (NCBI): 6999
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• UNIPROT ID: P48775
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

TDO2 (tryptophan 2,3-dioxygenase), IDO1 (indoleamine 2,3-dioxygenase 1) and IDO2 are three enzymes that catalyze the amino acid tryptophan into kynurenine in the kynurenine pathway (PMID: 23090118, 28469468). TDO2 plays an important role in neurological diseases such as Alzheimer's disease, Parkinson's disease and autism. Overexpression of TDO2 promoted tumor cell survival and was correlated with tumor grade and poor prognosis in triple negative breast cancer, brain tumors and esophageal squamous cell carcinoma. TDO2 may be a potential therapeutic target in some cancers. (PMID: 21976023, 30134247)