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- KD/KO Validated
TGF-beta 1 Antibody
TGF-beta 1 Polyclonal Antibody for IF, IHC, WB, ELISA
Cat no : 21898-1-AP
CED, DPD1, LAP, TGF beta 1, tgf beta1, TGFB, TGFB1, TGFbeta, tgfbeta1, tgf-beta1, TGFβ, TGFβ1, TGF-β1
|Positive WB detected in||mouse skin tissue, K-562 cells, HeLa cells, A549 cells, rat skin tissue|
|Positive IHC detected in||human placenta tissue, human prostate cancer tissue, mouse ovary tissue, mouse spleen tissue, rat ovary tissue|
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
|Positive IF detected in||HEK-293 cells|
|Western Blot (WB)||WB : 1:1000-1:5000|
|Immunohistochemistry (IHC)||IHC : 1:50-1:500|
|Immunofluorescence (IF)||IF : 1:50-1:500|
|Sample-dependent, check data in validation data gallery|
The 21898-1-AP immunogen is Fusion Protein TGF-beta 1 protein expressed in E. coli.
|Tested Reactivity||human, mouse, rat|
|Cited Reactivity||dog, human, zebrafish|
|Host / Isotype||Rabbit / IgG|
|Immunogen||TGF-beta 1 fusion protein Ag13591|
|Full Name||transforming growth factor, beta 1|
|Calculated molecular weight||44 kDa|
|Observed molecular weight||44 kDa|
|GenBank accession number||BC000125|
|Gene ID (NCBI)||7040|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
TGFB, also named as LAP and TGFB1, is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types. TGFB acts synergistically with TGFA in inducing transformation. It also acts as a negative autocrine growth factor. Dysregulation of TGFB activation and signaling may result in apoptosis. Many cells synthesize TGFB and almost all of them have specific receptors for it. TGFB positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. It is highly expressed in bone. Mutation of TGFB are the cause of Camurati-Engelmann disease (CED) which known as progressive diaphyseal dysplasia 1 (DPD1). Full length, inactive 44 kDa TGFB1 is cleaved into mature TGFB1 (13 kDa). TGFB1 also homodimerizes and heterodimerizes with TGFB2, so there is potential for multiple different band sizes in WB.
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The reviews below have been submitted by verified Proteintech customers who received an incentive forproviding their feedback.
Qingyuan (Verified Customer) (11-05-2019)
The antibody clearly shows one band with the right molecular weight size.