TIMP-2 Polyclonal antibody
TIMP-2 Polyclonal Antibody for IHC,ELISA
Host / Isotype
Rabbit / IgG
human, mouse, rat and More (1)
IHC, IF, ELISA
Cat no : 17353-1-AP
|Positive IHC detected in||human kidney tissue|
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
|Immunohistochemistry (IHC)||IHC : 1:50-1:500|
|Sample-dependent, check data in validation data gallery|
|WB||See 27 publications below|
|IHC||See 7 publications below|
|IF||See 1 publications below|
17353-1-AP targets TIMP-2 in IHC, IF, ELISA applications and shows reactivity with human, mouse, rat samples.
|Tested Reactivity||human, mouse, rat|
|Cited Reactivity||human, mouse, rat, bovine|
|Host / Isotype||Rabbit / IgG|
|Immunogen||TIMP-2 fusion protein Ag10051|
|Full Name||TIMP metallopeptidase inhibitor 2|
|Calculated molecular weight||220 aa, 24 kDa|
|GenBank accession number||BC052605|
|Gene ID (NCBI)||7077|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.|
The TIMPs are natural highly specific endogenous inhibitors of MMPs. Human TIMP family consists of four 21-28 kDa proteins known as TIMP1, TIMP2, TIMP3, and TIMP4 encoded by four paralogous genes.TIMPs are vital to the maintenance of ECM homeostasis primarily through their MMP inhibitory functions. TIMP2, a member of the TIMP family, regulates the proteolytic activity of all MMPs and is involved in cell differentiation, growth, migration, angiogenesis, and apoptosis. Urinary TIMP2 has been recently recognized as an early biomarker to predict Acute kidney injury (AKI) in critically ill patients.
|Product Specific Protocols|
|IHC protocol for TIMP-2 antibody 17353-1-AP||Download protocol|
|Click here to view our Standard Protocols|
Clin Cancer Res
RAB37 Hypermethylation Regulates Metastasis and Resistance to Docetaxel-Based Induction Chemotherapy in Nasopharyngeal Carcinoma.
Int J Biol Sci
TDG suppresses the migration and invasion of human colon cancer cells via the DNMT3A/TIMP2 axis.
11-epi-Sinulariolide Acetate Reduces Cell Migration and Invasion of Human Hepatocellular Carcinoma by Reducing the Activation of ERK1/2, p38MAPK and FAK/PI3K/AKT/mTOR Signaling Pathways.
Integration of exosomal miR-106a and mesothelial cells facilitates gastric cancer peritoneal dissemination.
Cryptotanshinone inhibits the growth and invasion of colon cancer by suppressing inflammation and tumor angiogenesis through modulating MMP/TIMP system, PI3K/Akt/mTOR signaling and HIF-1α nuclear translocation.
Cell Tissue Res