TLE3 Antibody 5 Publications

Rabbit Polyclonal| Catalog number: 11372-1-AP

Featured Product KD/KO validated

  • Print page
  • Download PDF

Be the first to review this product


-_-

Freight/Packing

Con: 34 μg/150 μl

Choose size:

Please visit your regions distributor:


Species specificity:
human, mouse, rat

Positive WB detected in:
HepG2 cells, HEK-293

Positive IP detected in:
HeLa cells

Positive IHC detected in:
human breast cancer tissue, human lung cancer tissue

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:2400
IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB
IHC : 1:20-1:200
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)

Calculated molecular weight:
772aa,83 kDa

Observed molecular weight:
83 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
TLE3

Synonyms
ESG, ESG3, FLJ39460, GRG3, HsT18976, KIAA1547, TLE3
Background

TLE3, also named as KIAA1547 and ESG3, belongs to the WD repeat Groucho/TLE family. It is a transcriptional corepressor that binds to a number of transcription factors. It inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. TLE3 is a member of the transducin-like enhancer of split (TLE) family of proteins that have been implicated in the tumorgenesis and classification of sarcomas. It is a candidate biomarker of response to taxane


Back
to top