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  • KD/KO Validated

TLR2 Polyclonal antibody

TLR2 Polyclonal Antibody for IHC, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat and More (1)

Applications

WB, IHC, ELISA

Conjugate

Unconjugated

Cat no : 17236-1-AP

Synonyms

CD282, TIL4, TLR2, toll like receptor 2



Tested Applications

Positive IHC detected inhuman tonsillitis tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Recommended dilution

ApplicationDilution
Immunohistochemistry (IHC)IHC : 1:50-1:500
Sample-dependent, check data in validation data gallery

Product Information

The immunogen of 17236-1-AP is TLR2 Fusion Protein expressed in E. coli.

Tested Reactivity human, mouse, rat
Cited Reactivityhuman, mouse, pig, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen TLR2 fusion protein Ag11079
Full Name toll-like receptor 2
Calculated molecular weight 784 aa, 90 kDa
GenBank accession numberBC033756
Gene symbol TLR2
Gene ID (NCBI) 7097
Conjugate Unconjugated
Form Liquid
Purification Method Antigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

TLR2, also known as CD282, is a member of the Toll-like receptor (TLR) family. TLR receptors are type I integral transmembrane glycoproteins which play a fundamental role in pathogen recognition and activation of innate immunity. TLR2 is expressed by immune cells including monocytes/macrophages, polymorphonuclear leukocytes (PMLs) and dendritic cells, and is also expressed by some no-immune cells including endothelial and epithelial cells (PMID: 21428911; 22566960). TLR2 forms heterodimers with TLR1 and TLR6, which is the initial step in a cascade of events leading to significant innate immune responses, development of adaptive immunity to pathogens and protection from immune sequelae related to infection with these pathogens (PMID: 22566960).

Protocols

Product Specific Protocols
IHC protocol for TLR2 antibody 17236-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
mouseIHC

J Stroke Cerebrovasc Dis

Global Transcriptomic Profiling of Cortex and Striatum: Cerebral Injury after Ischemia/Reperfusion in a Mouse Model.

Authors - Zhenying Zhao
ratWB

J Ethnopharmacol

Influence of the Total Saponin Fraction from Dioscorea nipponica Makino on TLR2/4-IL1R Receptor Singnal Pathway in Rats of Gouty Arthritis.

Authors - Qi Zhou
pigWB

Bone Joint Res

Suramin attenuates intervertebral disc degeneration by inhibiting NF-κB signalling pathway.

Authors - Zi-Miao Liu
pigWB

Mol Immunol

Isolation, characterization and transcriptome analysis of porcine deltacoronavirus strain HNZK-02 from Henan Province, China.

Authors - Xiao-Hui Jin
  • KD Validated
humanWB

Mol Cancer

The regulation of toll-like receptor 2 by miR-143 suppresses the invasion and migration of a subset of human colorectal carcinoma cells.

Authors - Guo Haiyan H
  • KD Validated