RANK/TNFRSF11A Polyclonal antibody

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  WB analysis using 32528-1-AP

  Various lysates were subjected to SDS PAGE followed by western blot with 32528-1-AP (TNFRSF11A antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

RANK/TNFRSF11A Polyclonal Antibody for WB, ELISA

Cat No. 32528-1-AP

Host / Isotype

Rabbit / IgG

Reactivity

mouse, rat

Applications

WB, ELISA

Synonyms

TNFRSF11A, TNF receptor superfamily member 11A , Receptor activator of NF-KB, RANK, Osteoclast differentiation factor receptor (ODFR)

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Tested Applications

• Positive WB detected in: C2C12 cells, rat liver tissue

Recommended dilution

• Western Blot (WB): WB : 1:500-1:2000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

32528-1-AP targets RANK/TNFRSF11A in WB, ELISA applications and shows reactivity with mouse, rat samples.

• Tested Reactivity: mouse, rat
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: Recombinant protein
• Full Name: Tumor necrosis factor receptor superfamily, member 11a
• Calculated Molecular Weight: 68 kDa
• Observed Molecular Weight: 70 kDa
• GenBank Accession Number: NM_001271235.1
• Gene Symbol: Tnfrsf11a
• Gene ID (NCBI): 498206
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity Purification
• UNIPROT ID: F1M8Z6
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

Tumor necrosis factor receptor superfamily member 11A (TNFRSF11A, also known as RANK, CD265, and ODFR) is the signaling receptor essential for osteoclast differentiation factor-mediated osteoclastogenesis and is involved in the regulation of interactions between T-cells and dendritic cells (PMID: 9878548). The RANK/RANKL/OPG system is a key regulator in bone resorption, and its dysregulation can lead to pathological bone loss (PMID: 37893470).