TNFSF15 Polyclonal antibody, PBS Only

• 

  WB analysis using 29899-1-AP (same clone as 29899-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 29899-1-AP (TNFSF15 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 29899-1-PBS in a different storage buffer formulation.

• 

  WB analysis using 29899-1-AP (same clone as 29899-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 29899-1-AP (TNFSF15 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 29899-1-PBS in a different storage buffer formulation.

• 

  WB analysis using 29899-1-AP (same clone as 29899-1-PBS)

  mouse small intestine tissue were subjected to SDS PAGE followed by western blot with 29899-1-AP (TNFSF15 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 29899-1-PBS in a different storage buffer formulation.

TNFSF15 Polyclonal Antibody for WB, Indirect ELISA

Cat No. 29899-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, Indirect ELISA

Synonyms

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Product Information

29899-1-PBS targets TNFSF15 in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

• Tested Reactivity: human, mouse, rat
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: Recombinant protein
• Full Name: tumor necrosis factor (ligand) superfamily, member 15
• Calculated Molecular Weight: 28 kDa
• Observed Molecular Weight: 28 kDa
• GenBank Accession Number: BC074941
• Gene Symbol: TNFSF15
• Gene ID (NCBI): 9966
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: O95150
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

Tumor necrosis factor ligand superfamily member 15 (TNFSF15) is also named as TL1 and VEGI. And it belongs to the tumor necrosis factor family. It is a receptor for TNFRSF25 and TNFRSF6B. VEGI induced degradation of IκB alpha, and nuclear translocation of p65 subunit of NFκB by activating NFκB (PMID: 10597252). TL1A mediates activation and apoptosis of NFκB in DR3-expressing cell lines (PMID: 11911831). Overexpression by cancer cells of a secretable VEGI fusion protein resulted in abrogation of xenograft tumor progression. The isoforms show endothelial cell-specific expression and are generated from a 17 kb human gene by alternative splicing (PMID: 11923219). In addition, VEGI can inhibit vascular endothelial growth and angiogenesis (in vitro) (PMID: 9872942).