TP53 Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 21891-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 85 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
A431 cells, HEK-293 cells, NIH/3T3 cells

Positive IP detected in:
A431 cells

Positive IHC detected in:
human endometrial cancer tissue, human endometrial cancer tissue, human ovary tumor tissue

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:50-1:500
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
tumor protein p53

Calculated molecular weight:
393aa,44 kDa

Observed molecular weight:
53 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
TP53

Synonyms
Antigen NY CO 13, Cellular tumor antigen p53, FLJ92943, LFS1, P53, Phosphoprotein p53, TP53, TRP53, tumor protein p53, Tumor suppressor p53
Background

TP53, also named as P53 and NY-CO-13, belongs to the p53 family that functions as a central mediator for organizing cellresponses to various stress and anticancer drugswith apoptosis,G1- phase arrest, and DNA repair.[PMID: 20346922]. In addition, TP53 appears to induce apoptosis through nontranscriptional cytoplasmic processes. In unstressed cells, TP53 is kept inactive essentially through the actions of the ubiquitin ligase MDM2, which inhibits TP53 transcriptional activity and ubiquitinates TP53 to promote its degradation[PMID: 22330136]. TP53 acts as a tumor suppressor in many tumor types and induces growth arrest or apoptosis depending on the physiological circumstances and cell type. It is involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process.


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