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  • KD/KO Validated

TRAF6 Polyclonal antibody

TRAF6 Polyclonal Antibody for ELISA

Host / Isotype

Rabbit / IgG


human and More (3)





Cat no : 12809-1-AP


RING finger protein 85, RNF85, TRAF6

Recommended dilution

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

12809-1-AP targets TRAF6 in WB, IF, ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Cited Reactivityhuman, mouse, rat, sheep
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen TRAF6 fusion protein Ag3555
Full Name TNF receptor-associated factor 6
Calculated Molecular Weight 522 aa, 60 kDa
GenBank Accession NumberBC031052
Gene Symbol TRAF6
Gene ID (NCBI) 7189
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

TRAF6 is a member of the TNF receptor associated factor (TRAF) protein family. TRAF6 is recognized as a signal transducer, which activates the NF-κB pathway in response to pro-inflammatory cytokines. TRAF6 has E3 ligase activity and is responsible for inducing Lys-63 (K63)-linked poly-ubiquitination chains, functioning together with E2 Ubc13/Uev1A complex to mediate IKK activation TRAF6 plays a crucial role in the regulation of the innate and adaptive immune responses.


humanWB, IF

Nat Immunol

Kinases Mst1 and Mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity.

Authors - Jing Geng


TRIM59 regulates autophagy through modulating both the transcription and the ubiquitination of BECN1.

Authors - Tianyu Han
  • KD Validated

Front Immunol

Emodin Alleviates Sodium Taurocholate-Induced Pancreatic Acinar Cell Injury via MicroRNA-30a-5p-Mediated Inhibition of High-Temperature Requirement A/Transforming Growth Factor Beta 1 Inflammatory Signaling.

Authors - Hong Xiang

Mol Cancer Res

TAGLN Is Downregulated by TRAF6-Mediated Proteasomal Degradation in Prostate Cancer Cells.

Authors - Fuping Wen

Front Pharmacol

Protective Effects of Dioscin against Lipopolysaccharide-Induced Acute Lung Injury through Inhibition of Oxidative Stress and Inflammation.

Authors - Hong Yao

Eur J Immunol

Gx-50 reduces β-amyloid-induced TNF-α, IL-1β, NO and PGE2 expression and inhibits NF- κB signaling in a mouse model of Alzheimer's disease.

Authors - Shi Shi