Product Information
12809-1-AP targets TRAF6 in WB, IF, ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Cited Reactivity | human, mouse, rat, sheep |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag3555 Product name: Recombinant human TRAF6 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 221-522 aa of BC031052 Sequence: ILIREQMPNHYDLDCPTAPIPCTFSTFGCHEKMQRNHLARHLQENTQSHMRMLAQAVHSLSVIPDSGYISEVRNFQETIHQLEGRLVRQDHQIRELTAKMETQSMYVSELKRTIRTLEDKVAEIEAQQCNGIYIWKIGNFGMHLKCQEEEKPVVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFVHTMQGEYDSHLPWPFQGTIRLTILDQSEAPVRQNHEEIMDAKPELLAFQRPTIPRNPKGFGYVTFMHLEALRQRTFIKDDTLLVRCEVSTRFDMGSLRREGFQPRSTDAGV Predict reactive species |
| Full Name | TNF receptor-associated factor 6 |
| Calculated Molecular Weight | 522 aa, 60 kDa |
| GenBank Accession Number | BC031052 |
| Gene Symbol | TRAF6 |
| Gene ID (NCBI) | 7189 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q9Y4K3 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA. |
Background Information
TRAF6 is a member of the TNF receptor associated factor (TRAF) protein family. TRAF6 is recognized as a signal transducer, which activates the NF-κB pathway in response to pro-inflammatory cytokines. TRAF6 has E3 ligase activity and is responsible for inducing Lys-63 (K63)-linked poly-ubiquitination chains, functioning together with E2 Ubc13/Uev1A complex to mediate IKK activation TRAF6 plays a crucial role in the regulation of the innate and adaptive immune responses.
Publications
What published studies show
TRAF6 Polyclonal antibody (Cat# 12809-1-AP) has accumulated 19 citations across 18 journals, including Nature Immunology, Autophagy, European Journal of Immunology, Acta Pharmacologica Sinica, and International Journal of Molecular Medicine. The cited research covers fields such as inflammation, pyroptosis, autophagy, breast and prostate cancer, neurodegeneration, ischemic stroke, hepatic and pulmonary injury, atherosclerosis, and arthritis, with applications primarily in Western blot and immunofluorescence.
| Species | Application | Title |
|---|---|---|
Mil Med Res Propionate and butyrate attenuate macrophage pyroptosis and osteoclastogenesis induced by CoCrMo alloy particles | ||
Nat Immunol Kinases Mst1 and Mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity. | ||
Autophagy TRIM59 regulates autophagy through modulating both the transcription and the ubiquitination of BECN1.
| ||
Acta Pharmacol Sin Long non-coding RNA STMN1P2 promotes breast cancer doxorubicin resistance by inhibiting pyroptosis through the hnRNPU-EZH2-TARF6-MALT1-caspase-1 pathway | ||
Int J Mol Med Protective effect of naringin against the LPS-induced apoptosis of PC12 cells: Implications for the treatment of neurodegenerative disorders. | ||
Front Immunol Emodin Alleviates Sodium Taurocholate-Induced Pancreatic Acinar Cell Injury via MicroRNA-30a-5p-Mediated Inhibition of High-Temperature Requirement A/Transforming Growth Factor Beta 1 Inflammatory Signaling. |
