TREM2 Polyclonal antibody

TREM2 Polyclonal Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG


Human, mouse and More (1)





Cat no : 27599-1-AP


TREM 2, TREM2, Trem2a, Trem2b, Trem2c

Tested Applications

Positive WB detected inTHP-1 cells

Recommended dilution

Western Blot (WB)WB : 1:500-1:2000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

27599-1-AP targets TREM2 in WB, ELISA applications and shows reactivity with Human, mouse samples.

Tested Reactivity Human, mouse
Cited Reactivityhuman, mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen TREM2 fusion protein Ag26319
Full Name triggering receptor expressed on myeloid cells 2
Calculated Molecular Weight 222 aa, 25 kDa
Observed Molecular Weight26-32 kDa
GenBank Accession NumberBC032362
Gene Symbol TREM2
Gene ID (NCBI) 54209
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

TREM2 (triggering receptor expressed on myeloid cells 2) is a cell surface receptor belongs to TREM family that is expressed on osteoclast, dendritic cells, macrophages, nature killers, neutrophils and microglia (PMID: 19302484). TREM2 is localized predominantly in the Golgi complex, but also shuttles to and from the cell surface in endocytic and exocytic vesicles (PMID: 16675145). TREM2 associates with DAP12 to initiate the intracellular signalling cascade via an immunoreceptor tyrosine-based activation motif (ITAM) domain and tyrosine-kinases (PMID: 23977213).


Product Specific Protocols
WB protocol for TREM2 antibody 27599-1-APDownload protocol
FC protocol for TREM2 antibody 27599-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols



Cell Death Dis

Heterogeneity of tumor microenvironment is associated with clinical prognosis of non-clear cell renal cell carcinoma: a single-cell genomics study.

Authors - Wen-Jin Chen

Sci Adv

TREM2 inhibition triggers antitumor cell activity of myeloid cells in glioblastoma

Authors - Rui Sun

Front Immunol

Identification of TREM2-positive tumor-associated macrophages in esophageal squamous cell carcinoma: implication for poor prognosis and immunotherapy modulation

Authors - Hongmu Li

Nat Commun

Soluble TREM2 ameliorates tau phosphorylation and cognitive deficits through activating transgelin-2 in Alzheimer's disease

Authors - Xingyu Zhang

Brain Res

TREM2 regulates BV2 microglia activation and influences corticosterone-induced neuroinflammation in depressive disorders

Authors - Jingjing Shi

Cell Death Dis

TREM2 deficiency impairs the energy metabolism of Schwann cells and exacerbates peripheral neurological deficits

Authors - Nannan Zhang