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TRPC6 Polyclonal antibody
TRPC6 Polyclonal Antibody for FC, IF, IHC, IP, WB, ELISA
Cat no : 18236-1-AP
Validation Data Gallery
|Positive WB detected in||mouse brain, COLO 320 cells, mouse lung tissue|
|Positive IP detected in||mouse lung tissue|
|Positive IHC detected in||human placenta tissue|
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
|Positive IF detected in||HeLa cells|
|Positive FC detected in||A549 cells|
|Western Blot (WB)||WB : 1:500-1:1000|
|Immunoprecipitation (IP)||IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB|
|Immunohistochemistry (IHC)||IHC : 1:50-1:500|
|Immunofluorescence (IF)||IF : 1:200-1:800|
|Sample-dependent, check data in validation data gallery|
18236-1-AP targets TRPC6 in WB, IP, IHC, IF, FC, ELISA applications and shows reactivity with human, mouse samples.
|Tested Reactivity||human, mouse|
|Cited Reactivity||human, mouse, rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||TRPC6 fusion protein Ag12976|
|Full Name||transient receptor potential cation channel, subfamily C, member 6|
|Calculated molecular weight||931 aa, 106 kDa|
|Observed molecular weight||100-110 kDa|
|GenBank accession number||BC093658|
|Gene ID (NCBI)||7225|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.|
Transient receptor potential canonical (TRPC) channels mediate the influx of different types of cations through the cell membrane and are involved in many functions of the organism (PMID: 28508319). The TRPC subfamily consists of seven members, TRPC1, TRPC2, TRPC3, TRPC4, TRPC5, TRPC6, TRPC7 (PMID: 32872338). TRPC6 is a Ca(2+)-permeable non-selective cation channel expressed in most human tissues. TRPC6 has been considered as potential therapeutic targets for malignant glioma treatment (PMID: 35489424).
|Product Specific Protocols|
|WB protocol for TRPC6 antibody 18236-1-AP||Download protocol|
|IHC protocol for TRPC6 antibody 18236-1-AP||Download protocol|
|IF protocol for TRPC6 antibody 18236-1-AP||Download protocol|
|IP protocol for TRPC6 antibody 18236-1-AP||Download protocol|
|Click here to view our Standard Protocols|
Regenerative Metaplastic Clones in COPD Lung Drive Inflammation and Fibrosis.
Nongenetic optical modulation of neural stem cell proliferation and neuronal/glial differentiation.
Proc Natl Acad Sci U S A
TRPC6 channel translocation into phagosomal membrane augments phagosomal function.
Deciphering the pharmacological mechanisms of Rostellularia procumbens (L) Nees. Extract alleviates adriamycin-induced nephropathy in vivo and in vitro
Br J Pharmacol
Catalpol Alleviates Adriamycin-Induced Nephropathy by Activating the SIRT1 Signalling Pathway In Vivo and In Vitro.
Amelioration of circadian disruption and calcium-handling protein defects by choline alleviates cardiac remodeling in abdominal aorta coarctation rats.