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  • KD/KO Validated

TRPV4 Polyclonal antibody

TRPV4 Polyclonal Antibody for IHC, ELISA

Host / Isotype

Rabbit / IgG


human, mouse, rat





Cat no : 20987-1-AP


Osm 9 like TRP channel 4, OTRPC4, TRP12, TRPV4, VR OAC, VRL 2, VRL2, VROAC

Tested Applications

Positive IHC detected inhuman brain tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Recommended dilution

Immunohistochemistry (IHC)IHC : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

20987-1-AP targets TRPV4 in IHC, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Cited Reactivityhuman, mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen Peptide
Full Name transient receptor potential cation channel, subfamily V, member 4
Calculated Molecular Weight 98 kDa
GenBank Accession NumberNM_021625
Gene Symbol TRPV4
Gene ID (NCBI) 59341
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

TRPV4, also named as VRL2 and VROAC, belongs to the transient receptor family and TrpV subfamily. It is a non-selective calcium permeant cation channel protein which involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. It is activated by low pH, citrate and phorbol esters. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. Defects in TRPV4 are the cause of brachyolmia type 3 (BRAC3), spondylometaphyseal dysplasia Kozlowski type (SMDK) and metatropic dysplasia (MTD). Multiple transcript variants encoding different isoforms have been found.


Product Specific Protocols
IHC protocol for TRPV4 antibody 20987-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols




Cannabidiol inhibits human glioma by induction of lethal mitophagy through activating TRPV4.

Authors - Tengfei Huang
  • KD Validated

Cell Death Dis

Inhibition of TRPV4 remodels single cell polarity and suppresses the metastasis of hepatocellular carcinoma

Authors - Jian Liu

Environ Pollut

Exposure to both formaldehyde and high relative humidity exacerbates allergic asthma by activating the TRPV4-p38 MAPK pathway in Balb/c mice.

Authors - Jiufei Duan

Sci Rep

Phosphodiesterase 3B (PDE3B) regulates NLRP3 inflammasome in adipose tissue.

Authors - Faiyaz Ahmad


TRPV4 inhibitor HC067047 produces antidepressant-like effect in LPS-induced depression mouse model.

Authors - Wei Li

Cell Mol Bioeng

The mechanosensitive ion channel TRPV4 is a regulator of lung development and pulmonary vasculature stabilization.

Authors - Joshua T Morgan