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  • KD/KO Validated

TUSC3 Polyclonal antibody

TUSC3 Polyclonal Antibody for WB,ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB,ELISA

Conjugate

Unconjugated

Cat no : 16039-1-AP

Synonyms

M33, MRT7, N33, OST3A, Protein N33, tumor suppressor candidate 3, TUSC3



Tested Applications

Positive WB detected inrat testis tissue, HeLa cells

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:200-1:1000
Sample-dependent, check data in validation data gallery

Product Information

16039-1-AP targets TUSC3 in WB,ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Cited Reactivity human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen TUSC3 fusion protein Ag8912
Full Name tumor suppressor candidate 3
Calculated molecular weight 347 aa, 40 kDa
Observed molecular weight 35-40 kDa
GenBank accession numberBC010370
Gene symbol TUSC3
Gene ID (NCBI) 7991
Conjugate Unconjugated
Form Liquid
Purification Method Antigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

TUSC3 (tumor suppressor candidate 3), originally named N33, is a potential tumor supressor gene. Decreased expression of TUSC3 has been found in various cancers, including prostate cancer, pancreas cancer and ovary cancer. TUSC3 also known as OST3A, is identified as a part of the oligosaccharyl-transferase (OST) complex and plays a crucial role in protein N-glycosylation. TUSC3 mutations have been found in families with non-syndromic autosomal recessive mental retardation.

Protocols

Product Specific Protocols
WB protocol for TUSC3 antibody 16039-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
humanWB

Proc Natl Acad Sci U S A

Mutations in MAGT1 lead to a glycosylation disorder with a variable phenotype.

Authors - Eline Blommaert
humanWB

Sci Rep

Mammalian cells lacking either the cotranslational or posttranslocational oligosaccharyltransferase complex display substrate-dependent defects in asparagine linked glycosylation.

Authors - Natalia A Cherepanova
  • KD Validated
humanWB

J Cell Biol

Oxidoreductase activity is necessary for N-glycosylation of cysteine-proximal acceptor sites in glycoproteins.

Authors - Natalia A Cherepanova
  • KD Validated

Nat Commun

miRNA-mediated TUSC3 deficiency enhances UPR and ERAD to promote metastatic potential of NSCLC.

Authors - Young-Jun Jeon