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- KD/KO Validated
Transgelin-2-specific Polyclonal antibody
Transgelin-2-specific Polyclonal Antibody for FC, IF, IHC, IP, WB,ELISA
Host / Isotype
Rabbit / IgG
Human and More (1)
WB, IP, IHC, IF, FC, ELISA
Cat no : 15508-1-AP
Validation Data Gallery
|Positive WB detected in||HeLa cells, HEK-293 cells|
|Positive IP detected in||L02 cells|
|Positive IHC detected in||human kidney tissue, human liver tissue|
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
|Positive IF detected in||HepG2 cells|
|Positive FC detected in||HepG2 cells|
|Western Blot (WB)||WB : 1:500-1:1000|
|Immunoprecipitation (IP)||IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB|
|Immunohistochemistry (IHC)||IHC : 1:20-1:200|
|Immunofluorescence (IF)||IF : 1:10-1:100|
|Sample-dependent, check data in validation data gallery|
|KD/KO||See 2 publications below|
|WB||See 6 publications below|
|IHC||See 1 publications below|
|IF||See 1 publications below|
|IP||See 1 publications below|
15508-1-AP targets Transgelin-2-specific in WB, IP, IHC, IF, FC, ELISA applications and shows reactivity with Human samples.
|Host / Isotype||Rabbit / IgG|
|Full Name||transgelin 2|
|Calculated molecular weight||22 kDa|
|Observed molecular weight||22 kDa|
|GenBank accession number||NM_003564|
|Gene ID (NCBI)||8407|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.|
The transgelin family is a group of proteins that belong to 22 kDa actin-related corpnin superfamily. Of all three isoforms, transgelin 1 is the best characterized. Transgelin 1, also known as SM22 alpha, is a specific marker for differentiated smooth muscle cells. Transgelin 2, also known as SM22 beta, is expressed by both smooth muscle and non-smooth muscle cells in a temporally and spatially regulated pattern. Trangenlin 3, also known as NP25, is only found in highly differentiated neuronal cells. This antibody can bind transgelin 2 specifically, but not trangelin 1 or 3.
|Product Specific Protocols|
|WB protocol for Transgelin-2-specific antibody 15508-1-AP||Download protocol|
|IHC protocol for Transgelin-2-specific antibody 15508-1-AP||Download protocol|
|IF protocol for Transgelin-2-specific antibody 15508-1-AP||Download protocol|
|IP protocol for Transgelin-2-specific antibody 15508-1-AP||Download protocol|
|FC protocol for Transgelin-2-specific antibody 15508-1-AP||Download protocol|
|Click here to view our Standard Protocols|
An Essential NRP1-Mediated Role for Tagln2 in Gastric Cancer Angiogenesis.
Cancer Cell Int
MiR-613 inhibits the proliferation, migration, and invasion of papillary thyroid carcinoma cells by directly targeting TAGLN2.
Transgelin 2 participates in lovastatin-induced anti-angiogenic effects in endothelial cells through a phosphorylated myosin light chain-related mechanism.
Biochem Biophys Res Commun
Transgelin-2 contributes to proliferation and progression of hepatocellular carcinoma via regulating Annexin A2.
J Gastroenterol Hepatol
The tumor-suppressive function of miR-1 by targeting LASP1 and TAGLN2 in esophageal squamous cell carcinoma.
MOBT Alleviates Pulmonary Fibrosis through an lncITPF-hnRNP-l-Complex-Mediated Signaling Pathway