UPK3B Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 15709-1-AP

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Con: 20 μg/150 μl

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Species specificity:
human, mouse

Positive IP detected in:
mouse testis tissue

Positive IHC detected in:
human bladder tissue

Recommended dilution:
IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
uroplakin 3B

Calculated molecular weight:
34 kDa

Observed molecular weight:
34 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
UPK3B

Synonyms
FLJ32198, P35, UP3b, UPIIIb, UPK3B, uroplakin 3B, Uroplakin IIIb
Background

Uroplakins are a group of urothelial differentiation-related membrane proteins. They are components of the asymmetric unit membrane (AUM), which forms the apical plaques of mammalian urothelium and is believed to play a role in strengthening the urothelial apical surface thus preventing the cells from rupturing during bladder distention (PMID: 8175808). Uroplakin-3b (UPK3B), also named as p35, is a single-pass type I membrane protein. This protein dimerizes with uroplakin-1b (UPK1B) to exit out of endoplasmic reticulum, which is is an important early step in urothelial plaque assembly (PMID: 12446744).


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